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Titolo:
HUMAN CD38, A LEUKOCYTE RECEPTOR AND ECTOENZYME, IS A MEMBER OF A NOVEL EUKARYOTIC GENE FAMILY OF NICOTINAMIDE ADENINE DINUCLEOTIDE(-CONVERTING ENZYMES - EXTENSIVE STRUCTURAL HOMOLOGY WITH THE GENES FOR MURINEBONE-MARROW STROMAL CELL ANTIGEN-1 AND APLYSIAN ADP-RIBOSYL CYCLASE())
Autore:
FERRERO E; MALAVASI F;
Indirizzi:
UNIV TURIN,DEPT GENET BIOL & MED CHEM,CELL BIOL LAB,VIA SANTENA 19 I-10126 TURIN ITALY UNIV ANCONA,SCH MED,INST BIOL & GENET ANCONA ITALY
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 159, anno: 1997,
pagine: 3858 - 3865
SICI:
0022-1767(1997)159:8<3858:HCALRA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; BRUTON TYROSINE KINASE; NAD GLYCOHYDROLASE; SURFACE-MOLECULE; 2ND-MESSENGER ENZYME; SIGNAL-TRANSDUCTION; HUMAN-LYMPHOCYTES; ECTO-ENZYME; B-CELLS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
E. Ferrero e F. Malavasi, "HUMAN CD38, A LEUKOCYTE RECEPTOR AND ECTOENZYME, IS A MEMBER OF A NOVEL EUKARYOTIC GENE FAMILY OF NICOTINAMIDE ADENINE DINUCLEOTIDE(-CONVERTING ENZYMES - EXTENSIVE STRUCTURAL HOMOLOGY WITH THE GENES FOR MURINEBONE-MARROW STROMAL CELL ANTIGEN-1 AND APLYSIAN ADP-RIBOSYL CYCLASE())", The Journal of immunology, 159(8), 1997, pp. 3858-3865

Abstract

The human leukocyte Ag CD38 is a 45-kDa type II membrane glycoproteinthat functions both as a transmembrane signaling receptor and as an ectoenzyme. CD38 can transmit positive or negative signals regulating Tand B lymphocyte proliferation and differentiation and can enzymatically convert nicotinamide adenine dinucleotide to cyclic ADP-ribose, a potent intracellular calcium releaser. To begin the genetic analysis of CD38, we have isolated and characterized the human CD38 gene, previously mapped to chromosome 4. Human CD38 is encoded by a single copy gene that extends over >62 kb and consists of eight exons and seven introns, including a very long intron that interrupts the 5' coding region. The 5' upstream region of the gene is characterized by the absence of canonical TATA and CAAT boxes, the presence of a GC-rich tract immediately upstream of the initiator codon, several transcription start sites, and potential binding sites for the immunologic transcription factors T cell-specific transcription factor alpha, nuclear factor-IL-6, and interferon responsive factor-1. Comparison of the genomic structure of human CD38 with that of the genes for murine bone marrow stromal Ag bone marrow stromal cell antigen 1/BP-3 and aplysian ADP-ribosyl cyclase, which encode proteins related to CD38 in sequence and function,reveals their striking structural similarity. This strongly suggests that the three genes evolved from a common ancestor from which CD38 and bone marrow stromal cell antigen 1 arose by gene duplication before the divergence of humans and rodents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:10:08