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Titolo:
THE IMPORTANCE OF INTERMEDIATE FILAMENTS IN THE ADAPTATION OF TISSUESTO MECHANICAL-STRESS - EVIDENCE FROM GENE KNOCKOUT STUDIES
Autore:
GALOU M; GAO J; HUMBERT J; MERICSKAY M; LI ZL; PAULIN D; VICART P;
Indirizzi:
UNIV PARIS 07,LAB BIOL MOL DIFFERENTIAT,25 RUE DR ROUX F-75015 PARIS FRANCE INST PASTEUR F-75015 PARIS FRANCE
Titolo Testata:
Biology of the cell
fascicolo: 2, volume: 89, anno: 1997,
pagine: 85 - 97
SICI:
0248-4900(1997)89:2<85:TIOIFI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; EPIDERMOLYSIS-BULLOSA SIMPLEX; AMYOTROPHIC-LATERAL-SCLEROSIS; STRATIFIED SQUAMOUS EPITHELIA; FAMILIAL CARDIOMYOPATHY; HUMAN KERATIN-14; CULTURED-CELLS; NUCLEOTIDE-SEQUENCE; SKELETAL-MUSCLE; SCRAPIE PRIONS;
Keywords:
CYTOSKELETON; DESMIN; INTERMEDIATE FILAMENTS; KNOCKOUT; STRESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
106
Recensione:
Indirizzi per estratti:
Citazione:
M. Galou et al., "THE IMPORTANCE OF INTERMEDIATE FILAMENTS IN THE ADAPTATION OF TISSUESTO MECHANICAL-STRESS - EVIDENCE FROM GENE KNOCKOUT STUDIES", Biology of the cell, 89(2), 1997, pp. 85-97

Abstract

Research over the past few years on the function of intermediate filaments in cells in culture has not produced convincing results, becausethe key role of intermediate filaments is within tissues and at certain periods of development. Only recently the technique of gene knockout has been used to examine intermediate filaments in mice and has provided the first evidence that intermediate filaments are directly involved in cell resilience and the maintenance of tissue integrity. Knockout of the gene encoding keratin K8 is lethal in the embryo, and results in hepatic or intestinal lesions, while knockout of the K14 or K10 genes leads to rupture of stratified epithelia. Knockout of the gene encoding desmin causes the rupture of skeletal and cardiac muscle, and collapse of blood vessel walls. Knockout of the gene coding for GFAP leads to a loss of cerebral white matter, and knockout of the gene coding for vimentin causes degeneration of the cerebellar Purkinje cells. The results reveal the lack of compensation by another intermediate filament. Tissues without intermediate filaments fall apart; they are mechanically unstable, unable to resist physical stress, and this leads to cell degeneration. By maintaining the shape and plasticity of the cell, the intermediate filament network acts as an integrator within thecell space. The state of mechanical force imposed on a tissue or a cell can alter the shape of certain elements of the cytoskeleton and thus participate to the control of cell functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:59:43