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Titolo:
SIMPLIFIED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN SERUM FROM PATIENTS COMEDICATED WITH OTHER PSYCHOTROPIC-DRUGS
Autore:
OLESEN OV; LINNET K;
Indirizzi:
AARHUS UNIV HOSP,HOSP PSYCHIAT,CLIN BIOCHEM LAB,DEPT BIOL PSYCHIAT,INST BASIC RES PSYCHIAT DK-8240 RISSKOV DENMARK
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 1-2, volume: 698, anno: 1997,
pagine: 209 - 216
SICI:
0378-4347(1997)698:1-2<209:SHLMFD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-SCHIZOPHRENIC PATIENTS; ELECTROCHEMICAL DETECTION; HALOPERIDOL; PLASMA; PHARMACOKINETICS;
Keywords:
RISPERIDONE; 9-HYDROXYRISPERIDONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
O.V. Olesen e K. Linnet, "SIMPLIFIED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN SERUM FROM PATIENTS COMEDICATED WITH OTHER PSYCHOTROPIC-DRUGS", Journal of chromatography B. Biomedical sciences and applications, 698(1-2), 1997, pp. 209-216

Abstract

A HPLC method was developed for determination of risperidone and its therapeutically active main metabolite 9-hydroxyrisperidone in serum. After a single-step liquid-liquid extraction the analytes were separated on a C-18 column and measured by UV detection at 280 nm. Inter-day coefficient of variation was <7% for both compounds at serum levels occurring in patients treated with ordinary doses. Studies of analyticalinterference showed that the most commonly coadministered antidepressants and benzodiazepines did not interfere. Some conventional low doseneuroleptics and clozapine did interfere, but this is of minor importance, because risperidone is intended as an alternative to these drugs. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:47:09