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Titolo:
SEGREGATION OF THE SOMITIC LINEAGES
Autore:
POURQUIE O;
Indirizzi:
CNRS,UMR 9943,LGPD,INST BIOL DEV MARSEILLE,CAMPUS LUMINY,CASE 907 F-13288 MARSEILLE 09 FRANCE
Titolo Testata:
MS. Medecine sciences
fascicolo: 10, volume: 13, anno: 1997,
pagine: 1145 - 1156
SICI:
0767-0974(1997)13:10<1145:SOTSL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
FRE
Soggetto:
SONIC HEDGEHOG; CHICK-EMBRYO; CELL LINEAGE; NEURAL-TUBE; SCLEROTOME INDUCTION; DIFFUSIBLE FACTORS; MUSCLE DEVELOPMENT; PAX-3 EXPRESSION; GENE-EXPRESSION; QUAIL EMBRYOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
O. Pourquie, "SEGREGATION OF THE SOMITIC LINEAGES", MS. Medecine sciences, 13(10), 1997, pp. 1145-1156

Abstract

Manu mesodermal lineages of the vertebrate body originate from transient mesodermal structures called the somites. These metameric units appear as epithelial spheres arising from the paraxial mesoderm on both sides of the axial organs. The somites give rise to the striated muscles, the dorsal dermis, and the axial skeleton. Surgical manipulations on newly formed somites in the chick embryo have shown that they are essentially composed of uncommitted cells, thus suggesting that their differentiation is controlled by signals produced by their local environment. For example the notochord and the neural rude have been implicated in sclerotome induction whereas the lateral plate plays a role in the hypaxial muscle determination. Molecular players such as Sonic Hedgehog, BMP4 or the products of the Wnt genes have now been identified. Their role in the segregation of the different semitic lineage is being characterized using microsurgery approaches in the chick embryo or genetic analyzis of null mutants in the mouse, These factors affectingcell fate determination within the somite have three different kinds of effects: an induction of particular cell fate (notochord and sclerotome induction), a permissive or survival effect (Sonic Hedgehog and the sclerotome differentiation) or a repressive effect on differentiation (BMP4 and the muscle lineage).

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Documento generato il 05/04/20 alle ore 19:15:24