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Titolo:
SCAVENGING, SIGNALING AND ADHESION COUPLING IN MACROPHAGES - IMPLICATIONS FOR ATHEROGENESIS
Autore:
SCHMITZ G; ORSO E; ROTHE G; KLUCKEN J;
Indirizzi:
UNIV REGENSBURG,INST CLIN CHEM & LAB MED,FRANZ JOSEF STR ALLEE 11 D-93053 REGENSBURG GERMANY
Titolo Testata:
Current opinion in lipidology
fascicolo: 5, volume: 8, anno: 1997,
pagine: 287 - 300
SICI:
0957-9672(1997)8:5<287:SSAACI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; INTEGRIN-ASSOCIATED PROTEIN; RECEPTOR-RELATED-PROTEIN; LIPOPOLYSACCHARIDE (LPS)-BINDING PROTEIN; BONE-MARROW TRANSPLANTATION; OVARIAN TUMOR-MARKER; LPS BINDING-PROTEIN; E-DEFICIENT MICE; FC-GAMMA-RIII; UROKINASE RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
142
Recensione:
Indirizzi per estratti:
Citazione:
G. Schmitz et al., "SCAVENGING, SIGNALING AND ADHESION COUPLING IN MACROPHAGES - IMPLICATIONS FOR ATHEROGENESIS", Current opinion in lipidology, 8(5), 1997, pp. 287-300

Abstract

Integrins are in physical association and functional cooperation withother membrane proteins that include receptors with scavenger functions, glycosyl-phosphatidylinositol-linked receptors, the family of integrin associated multimembrane spanning signalling proteins and possibly other less characterized proteins with a coupling or signalling function, Monocyte adhesion, migration and differentiation to phagocytically active scavenger cells are directly coupled processes, involving integrins as common transducers for a panel of integrin-linked specific receptors, which assemble a master cluster to coordinate adhesion, migration, scavenging and associated metabolic pathways of the lysosomal and secretory route, and also processes involved in host response. As macrophages represent highly heterogeneous cells that have major phenotypical and functional differences associated with specific patterns of integrin expression, the functional cooperation of integrins with scavenger receptors has to be related to specialized subsets of monocytes and macrophages as well as to ligand specific effects which mediate receptor coupling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:16:41