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Titolo:
COMPLEMENT AND GLUTAMATE NEUROTOXICITY - GENOTYPIC INFLUENCES OF C5 IN A MOUSE MODEL OF HIPPOCAMPAL NEURODEGENERATION
Autore:
TOCCO G; MUSLEH W; SAKHI S; SCHREIBER SS; BAUDRY M; PASINETTI GM;
Indirizzi:
CUNY MT SINAI SCH MED,DEPT PSYCHIAT,1 GUSTAVE L LEVY PL NEW YORK NY 10029 CUNY MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 10029 CUNY MT SINAI SCH MED,BROOKDALE CTR MOL BIOL NEW YORK NY 10029 UNIV SO CALIF,HEDCO NEUROSCI PROGRAM LOS ANGELES CA 00000 UNIV SO CALIF,DEPT NEUROL LOS ANGELES CA 00000
Titolo Testata:
Molecular and chemical neuropathology
fascicolo: 3, volume: 31, anno: 1997,
pagine: 289 - 300
SICI:
1044-7393(1997)31:3<289:CAGN-G>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT BRAIN; AMPA RECEPTOR; HUMAN ASTROCYTES; MESSENGER-RNA; EXPRESSION; ANAPHYLATOXIN; ACTIVATION; MICROGLIA; RESPONSES; SYSTEM;
Keywords:
COMPLEMENT; C5A ANAPHYLATOXIN; GLUTAMATE RECEPTORS; EXCITOTOXIC LESION; AMPA RECEPTORS; ALZHEIMER DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Tocco et al., "COMPLEMENT AND GLUTAMATE NEUROTOXICITY - GENOTYPIC INFLUENCES OF C5 IN A MOUSE MODEL OF HIPPOCAMPAL NEURODEGENERATION", Molecular and chemical neuropathology, 31(3), 1997, pp. 289-300

Abstract

Using mice genetically deficient in the complement (C)-system component C5, this study explored a potential novel role of the C-system in Ca2+-mediated control of glutamate AMPA receptor functions. We found that Ca2+ preincubation of frozen brain tissue sections enhances AMPA binding capacity more dynamically in C5 deficient (C5(-)) than congenic C5 sufficient (C5(+)) mice. The Ca2+-mediated response was mostly localized to the CA3 and CA1 subdivisions of the pyramidal layers of the hippocampal formation. Ln C5(-) mice, kainic acid (KA) excitotoxicity that models hippocampal neurodegeneration abolished the Ca2+-mediated induction of hippocampal AMPA binding. The changes in AMPA binding preceded temporally and overlapped anatomically the appearance of apoptotic features in the same hippocampal neuron layers. C5(-) mice showed greater hippocampal neurodegeneration then C5(+) mice. NMDA binding controlled for specificity of glutamate-mediated changes and found no C5 genotypic influences. The study gives further credence to the role of the C-system in modifying the intensity and outcome during response to conditions leading to hippocampal neurodegeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:25:34