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Titolo:
ROLE OF I-1 IMIDAZOLINE RECEPTORS IN THE SYMPATHOINHIBITION PRODUCED BY INTRACISTERNALLY ADMINISTERED RILMENIDINE AND MOXONIDINE
Autore:
SZABO B; URBAN R;
Indirizzi:
UNIV FREIBURG,INST PHARMAKOL,HERMANN HERDER STR 5 D-79104 FREIBURG GERMANY
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 9, volume: 47, anno: 1997,
pagine: 1009 - 1015
SICI:
0004-4172(1997)47:9<1009:ROIIRI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; BRAIN-STEM; CONSCIOUS RABBITS; BINDING-SITES; ANTIHYPERTENSIVE AGENT; CARDIOVASCULAR ACTIONS; VENTROLATERAL MEDULLA; PREFERRING RECEPTORS; I1-IMIDAZOLINE SITES; SEROTONERGIC NEURONS;
Keywords:
ALPHA-2-ADRENOCEPTOR; BLOOD PRESSURE; CAS 23256-50-0; CAS 54187-04-1; CAS 75438-57-2; GUANABENZ; I-1 IMIDAZOLINE RECEPTOR; MOXONIDINE; RILMENIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
B. Szabo e R. Urban, "ROLE OF I-1 IMIDAZOLINE RECEPTORS IN THE SYMPATHOINHIBITION PRODUCED BY INTRACISTERNALLY ADMINISTERED RILMENIDINE AND MOXONIDINE", Arzneimittel-Forschung, 47(9), 1997, pp. 1009-1015

Abstract

The role of alpha(2)-adrenoceptors and I-1 imidazoline receptors in the cardiovascular effects of rilmenidine (GAS 54187-04-1), moxonidine (GAS 75438-57-2) and guanabenz (GAS 23256-50-0) was studied in conscious rabbits. In radioligand binding studies, rilmenidine and moxonidineare selective for Il imidazoline receptors (vs. alpha(2)-adrenoceptors) and guanabenz is selective for alpha(2)-adrenoceptors (vs. I-1 imidazoline receptors). Efaroxan (GAS 89197-00-2; selective for I-1 imidazoline receptors) and yohimbine (GAS 65-19-0; selective for alpha(2)-adrenoceptors) were used as antagonists. All drugs were injected into the cisterna magna. Guanabenz (1, 3 10 and 30 mu g kg(-1)), rilmenidine (1, 3, 10 and 30 mu g kg(-1)) and moxonidine (0.03, 0.1, 0.3 and 1 mu g kg(-1)) dose-dependently lowered blood pressure. heart rate and the plasma concentration of noradrenaline. In the antagonism experiments, guanabenz (10 mu g kg(-1)), rilmenidine (10 mu g kg(-1)) and moxonidine (0.3 mu g kg(-1)) were administered first; they caused equal hypotension. Injection of the agonists was followed by injection of efaroxan (0.3-1 mu g kg(-1)) or yohimbine (0.1-0.3 mu g kg(-1)). Efaroxan and yohimbine were equieffective at antagonizing the effects of guanabenz. In contrast, efaroxan was more effective than yohimbine at antagonizing the effects of rilmenidine and moxonidine. The results show that intracisternally administered guanabenz, rilmenidine and moxonidine causesympathoinhibition. alpha(2)-Adrenoceptors are responsible for the sympathoinhibition produced by guanabenz. In contrast, I-1 imidazoline receptors are involved in the sympathoinhibition caused by rilmenidine and moxonidine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:30:25