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Titolo:
IODINE-123-ALPHA-METHYL TYROSINE IN GLIOMAS - CORRELATION WITH CELLULAR DENSITY AND PROLIFERATIVE ACTIVITY
Autore:
KUWERT T; PROBSTCOUSIN S; WOESLER B; MORGENROTH C; LERCH H; MATHEJA P; PALKOVIC S; SCHAFERS M; WASSMANN H; GULLOTTA F; SCHOBER O;
Indirizzi:
UNIV MUNSTER,DEPT NUCL MED,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NEUROPATHOL D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NEUROSURG D-48129 MUNSTER GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 38, anno: 1997,
pagine: 1551 - 1555
SICI:
0161-5505(1997)38:10<1551:ITIG-C>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL TYROSINE; BRAIN-TUMORS; AMINO-ACIDS; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; METHIONINE UPTAKE; TL-201 SPECT; PET; CELLS; CARBON-11-METHIONINE;
Keywords:
RADIONUCLIDE IMAGING; GLIOMAS; SPECT; IODINE-123-ALPHA-METHYL TYROSINE; CELLULAR DENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T. Kuwert et al., "IODINE-123-ALPHA-METHYL TYROSINE IN GLIOMAS - CORRELATION WITH CELLULAR DENSITY AND PROLIFERATIVE ACTIVITY", The Journal of nuclear medicine, 38(10), 1997, pp. 1551-1555

Abstract

Amino acid transport rate in gliomas can be assessed using SPECT and the amino acid L-I-123-alpha-methyl tyrosine (IMT). This study attempted to correlate the uptake of IMT by gliomas with the proliferative activity and cellular density oi these neoplasms, Methods: The study used 27 patients with gliomas, including 18 patients with high-grade tumors and nine patients with low-grade neoplasms. Amino acid transport rate was determined using IMT and the triple-headed SPECT camera, Proliferative activity was immunohistochemically assessed as the relative number of cells expressing the Ki-67 nuclear antigen; cellular density was evaluated using light microscopy. Results: Relative IMT uptake correlated significantly with the proliferative fraction of tumor cells (r= 0.6, p < 0.001). There was no significant correlation between IMT uptake and cellular density (r = 0.25, p > 0.05), Conclusion: The uptake of the SPECT radiopharmaceutical IMT is related to proliferative activity rather than to the cellular density of gliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 04:36:23