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Titolo:
ARE NMDA ANTAGONISTIC PROPERTIES RELEVANT FOR ANTIPARKINSONIAN-LIKE ACTIVITY IN RATS - CASE OF AMANTADINE AND MEMANTINE
Autore:
DANYSZ W; GOSSEL M; ZAJACZKOWSKI W; DILL D; QUACK G;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,POB 11 13 53 D-60084 FRANKFURT GERMANY MERZ & CO,DEPT CENT ANALYT FRANKFURT GERMANY
Titolo Testata:
Journal of neural transmission. Parkinson's disease and dementia section
fascicolo: 3, volume: 7, anno: 1994,
pagine: 155 - 166
SICI:
0936-3076(1994)7:3<155:ANAPRF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE ANTAGONISTS; HUMAN FRONTAL-CORTEX; PARKINSONS-DISEASE; RECEPTOR ANTAGONISTS; INDUCED CATALEPSY; DRUGS MEMANTINE; BASAL GANGLIA; MK-801; RELEASE; MODEL;
Keywords:
CATALEPSY; HALOPERIDOL; LOCOMOTION; RESERPINE; ALPHA-METHYL-P-TYROSINE; ROTATION; SUBSTANTIA NIGRA LESION; AMANTADINE; MEMANTINE; MK-801; NMDA RECEPTOR ANTAGONISM; PLASMA LEVELS; BRAIN LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
W. Danysz et al., "ARE NMDA ANTAGONISTIC PROPERTIES RELEVANT FOR ANTIPARKINSONIAN-LIKE ACTIVITY IN RATS - CASE OF AMANTADINE AND MEMANTINE", Journal of neural transmission. Parkinson's disease and dementia section, 7(3), 1994, pp. 155-166

Abstract

Amantadine (25, 50, 100mg/kg), memantine (5, 10, 20mg/kg) and MK-801 (0.05, 0.1, 0.2mg/kg), all having NMDA channel blocking properties, were compared in three tests used for screening of antiparkinsonian agents in rats, namely: haloperidol-induced catalepsy, locomotor activity in monoamine depleted rats and rotation in rats with a unilateral substantia nigra lesion. Additionally, plasma levels of amantadine and memantine were assesssed to gain an insight into the concentration rangesachieved at behaviorally active doses. Amantadine and (+)-MK-801 produced dose-dependent inhibition of haloperidol-induced catalepsy while memantine was less efficacious producing clear-cut anticataleptic action at a dose of 10 mg/kg only but failing at 20mg/kg due to myorelaxant activity. All agents attenuated sedation in monoamine depleted rats with amantadine being the least and MK-801 being the most effective. The same rank order of efficacy was seen in inducing ipsilateral rotations in rats after a substantia nigra lesion. On the basis of the present study and published data, it can be assumed that the doses of amantadine, memantine and MK-801 showing antiparkinsonian-like activity in animals result in plasma levels leading to NMDA antagonism. However, in the haloperidol-induced catalepsy test the efficacy of amantadine was higher than memantine, while the opposite was true for rotation and reserpine-induced sedation indicating pharmacodynamic differences between both agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:53:21