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Titolo:
EVALUATION OF RIGHT AND LEFT-VENTRICULAR VOLUME AND EJECTION FRACTIONUSING A MATHEMATICAL CARDIAC TORSO PHANTOM
Autore:
PRETORIUS PH; XIA WS; KING MA; TSUI BMW; PAN TS; VILLEGAS BJ;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,DEPT NUCL MED,55 LAKE AVE N WORCESTER MA 01655 UNIV MASSACHUSETTS,MED CTR,DEPT NUCL MED WORCESTER MA 01655 UNIV N CAROLINA,DEPT BIOMED ENGN CHAPEL HILL NC 00000 UNIV ORANGE FREE STATE,DEPT BIOPHYS BLOEMFONTEIN SOUTH AFRICA
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 38, anno: 1997,
pagine: 1528 - 1535
SICI:
0161-5505(1997)38:10<1528:EORALV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY PULMONARY-HYPERTENSION; EMISSION COMPUTED-TOMOGRAPHY; EDGE-DETECTION METHOD; RADIONUCLIDE VENTRICULOGRAPHY; SCATTER CORRECTION; WINDOW METHOD; WALL MOTION; SPECT; QUANTITATION; QUANTIFICATION;
Keywords:
SPECT; VENTRICULAR VOLUME; EJECTION FRACTION; GATED BLOOD-POOL IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P.H. Pretorius et al., "EVALUATION OF RIGHT AND LEFT-VENTRICULAR VOLUME AND EJECTION FRACTIONUSING A MATHEMATICAL CARDIAC TORSO PHANTOM", The Journal of nuclear medicine, 38(10), 1997, pp. 1528-1535

Abstract

The availability of gated SPECT has increased the interest in the determination of volume and ejection fraction of the left ventricle (LV) for clinical diagnosis, However, the same indices for the right ventricle (RV) have been neglected, The objective of this investigation was to use a mathematical model of the anatomical distribution of activityin gated blood-pool imaging to evaluate the accuracy of two ventricular volume and ejection fraction determination methods, In this investigation, measurements from the RV were emphasized, Methods: The mathematical cardiac torso phantom, developed to study LV myocardium perfusion, was modified to simulate the radioactivity distribution of a Tc-99m-gated blood-pool study, Twenty mathematical cardiac torso phantom models of the normal heart with different LV volumes (122.3 +/- 11.0 ml),RV volumes (174.6 +/- 22.3 ml) and stroke volumes (75.7 +/- 3.3 ml) were randomly generated to simulate variations among patients. An analytical three-dimensional projector with attenuation and system responsewas used to generate SPECT projection sets, after which noise was added. The projections were simulated for 128 equidistant views in a 360 degrees rotation mode. Results: The radius of rotation was varied between 24 and 28 cm to mimic such variation in patient acquisitions, The 180 degrees and 360 degrees projection sets were reconstructed using the filtered backprojection reconstruction algorithm with Butterworth filtering. Comparison was made with and without application of the iterative Chang attenuation correction algorithm. Volumes were calculated using a modified threshold and edge detection method (hybrid threshold), as well as a count-based method, A simple background correction procedure was used with both methods, Conclusion: Results indicate that cardiac functional parameters can be measured with reasonable accuracy using both methods, However, the count-based method had a larger bias than the hybrid threshold method when RV parameters were determined for 180 degrees reconstruction without attenuation correction, This biasimproved after attenuation correction. The count-based method also tended to overestimate the end systolic volume slightly, An improved background correction could possibly alleviate this bias.

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Documento generato il 26/01/20 alle ore 00:37:39