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Titolo:
THE PROTECTIVE EFFECT OF ZINC-SULFATE PRETREATMENT AGAINST DUODENAL-ULCERS IN THE RAT
Autore:
TROSKOT B; SIMICEVIC VN; DODIG M; ROTKVIC I; IVANKOVIC D; DUVNJAK M;
Indirizzi:
UNIV ZAGREB,SCH MED,CLIN HOSP SESTRE MILOSRDNICE,DEPT GASTROENTEROL,VINOGRADSKA CESTA 29 ZAGREB 10000 CROATIA PLIVA PHARMACEUT CO,RES INST,BIOMED DEPT ZAGREB CROATIA UNIV ZAGREB,SCH MED,SCH PUBL HLTH ANDRIJA STAMPAR,DEPT STAT EPIDEMIOL& INFORMAT ZAGREB 41001 CROATIA
Titolo Testata:
BioMetals
fascicolo: 4, volume: 10, anno: 1997,
pagine: 325 - 329
SICI:
0966-0844(1997)10:4<325:TPEOZP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIULCEROGENIC ACTIVITY; ACEXAMATE; METALLOTHIONEIN; TISSUES; CADMIUM; SULFATE; DISEASE; LIVER;
Keywords:
CYSTEAMINE; CYTOPROTECTION; DUODENAL ULCER; RAT; ZINC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
B. Troskot et al., "THE PROTECTIVE EFFECT OF ZINC-SULFATE PRETREATMENT AGAINST DUODENAL-ULCERS IN THE RAT", BioMetals, 10(4), 1997, pp. 325-329

Abstract

Exogenously administered zinc compounds have been shown to possess antiulcer activity in the development of gastric lesions. The aim of this study was to investigate the effects of zinc sulphate pretreatment of rats on cysteamine-induced duodenal ulcers and to correlate them with changes in zinc serum and tissue levels. Atomic absorption spectrophotometry was used to determine zinc serum and tissue concentrations inall animal groups. Cysteamine produced marked duodenal ulceration in control animals 24 h after application, with an increase in endogenouszinc tissue concentrations and a marked decrease in serum concentrations, Zinc sulphate (20, 40 or 80 mg kg(-1)) applied per os one hour prior to cysteamine application inhibited the development of duodenal lesions in a dose-related manner, The application of zinc sulphate in a single intraperitoneal (i.p.) application (80 mg kg(-1)) did not, however, prevent the formation of duodenal lesions. In order to assess zinc absorption from the gastrointestinal tract, one group of rats received a single oral dose of zinc sulphate (80 mg kg(-1)) without cysteamine application, The observations of this study seem to indicate that zinc plays an important cytoprotective role in duodenal ulcer disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 09:48:30