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Titolo:
ISSUES IN MAPPING GENES FOR EATING DISORDERS
Autore:
ALLISON DB; FAITH MS;
Indirizzi:
ST LUKES ROOSEVELT HOSP,OBES RES CTR,1090 AMSTERDAM AVE,14TH FLOOR NEW YORK NY 10025 COLUMBIA UNIV COLL PHYS & SURG NEW YORK NY 10032
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 3, volume: 33, anno: 1997,
pagine: 359 - 368
SICI:
0048-5764(1997)33:3<359:IIMGFE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; DISCORDANT SIB PAIRS; LINKAGE DISEQUILIBRIUM; ANOREXIA-NERVOSA; SAMPLING CONSIDERATIONS; OLIGOGENIC DISEASE; MAJOR DEPRESSION; BULIMIA-NERVOSA; COMPLEX TRAITS; HUMANS;
Keywords:
EATING DISORDERS; GENE MAPPING; POWER; LINKAGE; EFFICIENT DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Allison e M.S. Faith, "ISSUES IN MAPPING GENES FOR EATING DISORDERS", Psychopharmacology bulletin, 33(3), 1997, pp. 359-368

Abstract

Recent twin studies show that both genetic and environmental factors contribute to the development of eating disorders. As in many other fields, there is much enthusiasm regarding the possibility of locating the specific genes that influence the risk of eating disorders. Advances in molecular and statistical technology have made this task more feasible than It was in the past, and continued enhancements in new technology are expected in the future. Despite these advances, the resources required to map a gene for traits as complex as eating disorders arelikely to be enormous. Researchers considering such an undertaking may wish to look for ways to reduce this demand, such as (1) using multivariate analyses, (2) studying intermediate quantitative phenotypes, (3) using large sibships, (4) analytic enhancements (e.g., multipoint analyses), (5) reconceptualizing power, (6) data pooling, and (7) disequilibrium mapping.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:04:47