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Titolo:
CENTRAL SEROTONIN ACTIVITY AND AGGRESSION - INVERSE RELATIONSHIP WITHPROLACTIN RESPONSE TO D-FENFLURAMINE, BUT NOT CSF 5-HIAA CONCENTRATION, IN HUMAN-SUBJECTS
Autore:
COCCARO EF; KAVOUSSI RJ; COOPER TB; HAUGER RL;
Indirizzi:
MED COLL PENN & HAHNEMANN UNIV,DEPT PSYCHIAT,SCH MED,CLIN NEUROSCI RES UNIT,3200 HENRY AVE PHILADELPHIA PA 19129
Titolo Testata:
The American journal of psychiatry
fascicolo: 10, volume: 154, anno: 1997,
pagine: 1430 - 1435
SICI:
0002-953X(1997)154:10<1430:CSAAA->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DEFICIT HYPERACTIVITY DISORDER; DISRUPTIVE BEHAVIOR DISORDERS; PERSONALITY-DISORDER; IMPULSIVE AGGRESSION; AMINE METABOLITES; CHALLENGE; ADOLESCENTS; CHILDREN; INDEXES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
E.F. Coccaro et al., "CENTRAL SEROTONIN ACTIVITY AND AGGRESSION - INVERSE RELATIONSHIP WITHPROLACTIN RESPONSE TO D-FENFLURAMINE, BUT NOT CSF 5-HIAA CONCENTRATION, IN HUMAN-SUBJECTS", The American journal of psychiatry, 154(10), 1997, pp. 1430-1435

Abstract

Objective: This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects. Method: The Life History of Aggression assessment scores of 24 subjects with personality disorders were compared with their lumbar CSF 5-HIAA concentrations and with their prolactin responses to d-fenfluramine challenge. Results: Aggression was significantly and inversely correlated with prolactin responses to d-fenfluramine challenge but not with lumbar CSF 5-HIAA concentrations in these subjects. Conclusions: Prolactin response to d-fenfluramine may be more sensitive than lumbar CSF 5-HIAA concentration indetecting a relationship between aggression and central serotonin activity in noncriminally violent human subjects.

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Documento generato il 14/07/20 alle ore 08:12:24