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Titolo:
RADIOLABELING CHARACTERISTICS OF NOVEL IMINOPHOSPHORANE LIGANDS WITH TC-99M
Autore:
OKARVI SM; ANGELOV CM; AKRAM I; CAVELL RG; MCEWAN AJB; SURESH MR;
Indirizzi:
UNIV ALBERTA,FAC PHARM & PHARMACEUT SCI EDMONTON AB T6G 2N8 CANADA UNIV ALBERTA,DEPT CHEM EDMONTON AB CANADA CROSS CANC INST EDMONTON AB T6G 1Z2 CANADA
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 10, volume: 39, anno: 1997,
pagine: 833 - 851
SICI:
0362-4803(1997)39:10<833:RCONIL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTACTIC PEPTIDE ANALOGS; BACTERIAL-INFECTION; COMPLEXES; TC-99M; SOMATOSTATIN; BIODISTRIBUTION; ANTIBODY; BINDING; SITES;
Keywords:
PHOSPHORUS-NITROGEN BIFUNCTIONAL LIGANDS; TC-99M-IMINOPHOSPHORANES; LABELING WITH TC-99M; RADIOLABELING WITH AND WITHOUT REDUCING AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Okarvi et al., "RADIOLABELING CHARACTERISTICS OF NOVEL IMINOPHOSPHORANE LIGANDS WITH TC-99M", Journal of labelled compounds & radiopharmaceuticals, 39(10), 1997, pp. 833-851

Abstract

A variety of unconventional phosphorus-nitrogen (P-N) backbone ligands have been synthesized with a unique, chemically flexible heterobifunctional ligand system that has the capability to complex with a radioactive metal ion and to link a bioactive peptide. We approach the synthesis of the iminophosphorane ligands (P-N) through the reaction of silylaminophosphines, T2NPR2 (T=SiMe3). The P-N compounds which are derived from the applications of these silylaminophosphine reactions with adiversity of organic substrates, have the capability to attach Tc-99mby means of a covalent bond. A further advantage of these type of chelating agents is their ability to selectively react with (TC)-T-99m ina +7 oxidation state and in the absence of reducing agent. This type of ligand presents the possibility of forming a metal-nitrogen a bond with a high oxidation-state early transition metal via the eliminationof Me3SiCl. The properties of the resulting chelates with these ligands can be readily modified by introducing a variety of substituents onthe P or N atoms (R or R'). Several studied P-N ligands have been shown to hold the potential for preparing stable Tc-99m-complexes with high labelling yield under the mild labelling conditions and with and without reducing agents. Furthermore, the labelled P-N compounds showed a high stability both when incubated with plasma and when challenged with excess amount of cysteine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:59:00