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Titolo:
SEROTONIN, AGGRESSION, AND PARENTAL PSYCHOPATHOLOGY IN CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER
Autore:
HALPERIN JM; NEWCORN JH; KOPSTEIN I; MCKAY KE; SCHWARTZ ST; SIEVER LJ; SHARMA V;
Indirizzi:
CUNY QUEENS COLL,DEPT PSYCHOL,65-30 KISSENA BLVD FLUSHING NY 11367 MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 00000 CUNY,SCH PSYCHOL DOCTORAL PROGRAM NEW YORK NY 00000
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 10, volume: 36, anno: 1997,
pagine: 1391 - 1398
SICI:
0890-8567(1997)36:10<1391:SAAPPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DISRUPTIVE BEHAVIOR DISORDERS; FAMILY HISTORY METHOD; 5-HYDROXYINDOLEACETIC ACID; PERSONALITY-DISORDERS; IMIPRAMINE BINDING; CONDUCT DISORDER; RHESUS-MONKEYS; D-FENFLURAMINE; ADOLESCENTS;
Keywords:
AGGRESSION; SEROTONIN; ATTENTION-DEFICIT HYPERACTIVITY DISORDER; PARENT PSYCHOPATHOLOGY; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Halperin et al., "SEROTONIN, AGGRESSION, AND PARENTAL PSYCHOPATHOLOGY IN CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER", Journal of the American Academy of Child and Adolescent Psychiatry, 36(10), 1997, pp. 1391-1398

Abstract

Objective: To explore the relationship between central serotonergic (5-HT) function and history of parental aggression in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder (ADHD). Method: History of psychiatric symptoms was assessed in the biological parents of 41 boys with ADHD. The relationship between 5-HT functionin aggressive and nonaggressive probands, as assessed via the prolactin response to fenfluramine (FEN) challenge, and parental history of aggression was examined. Results: Aggressive boys with a parental history of aggressive behavior had a significantly lower prolactin responseto FEN challenge than aggressive boys without a parental history of aggression. Nonaggressive boys had a prolactin response midway between those of the two aggressive subgroups, and their prolactin response did not vary as a function of parental aggression. Children subdivided on the basis of parental history of other psychiatric symptoms did not differ in their response to the FEN challenge. Conclusions: These dataindicate an association between parent aggressive behavior and lower 5-HT function in aggressive boys with ADHD but do not indicate the extent to which this association is environmentally and/or genetically transmitted. There may be different neurochemical mechanisms in familialand nonfamilial aggressive children, which have clinical implicationsfor pharmacological interventions.

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Documento generato il 19/01/20 alle ore 20:10:40