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Titolo:
EVIDENCE FOR INTRATHECAL SYNTHESIS OF ALTERNATIVE PATHWAY COMPLEMENT ACTIVATION PROTEINS IN EXPERIMENTAL MENINGITIS
Autore:
STAHEL PF; FREI K; FONTANA A; EUGSTER HP; AULT BH; BARNUM SR;
Indirizzi:
UNIV ALABAMA,DEPT MICROBIOL,BHSB 306,1918 UNIV BLVD BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT MICROBIOL,BHSB 306 BIRMINGHAM AL 35294 UNIV ZURICH HOSP,DEPT INTERNAL MED,CLIN IMMUNOL SECT ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT NEUROSURG ZURICH SWITZERLAND RUSH MED COLL,DEPT PEDIAT CHICAGO IL 60612
Titolo Testata:
The American journal of pathology
fascicolo: 4, volume: 151, anno: 1997,
pagine: 897 - 904
SICI:
0002-9440(1997)151:4<897:EFISOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BACTERIAL-MENINGITIS; CEREBROSPINAL-FLUID; FACTOR-ALPHA; PNEUMOCOCCAL MENINGITIS; MONOCLONAL-ANTIBODIES; CHEMOTACTIC ACTIVITY; TISSUE-DAMAGE; BRAIN EDEMA; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Stahel et al., "EVIDENCE FOR INTRATHECAL SYNTHESIS OF ALTERNATIVE PATHWAY COMPLEMENT ACTIVATION PROTEINS IN EXPERIMENTAL MENINGITIS", The American journal of pathology, 151(4), 1997, pp. 897-904

Abstract

Complement has been shown to contribute to intrathecal inflammation in bacterial meningitis, However, the cellular source of complement in the infected central nervous system has not been determined, In this study, we analyzed protein and mRNA expression of two alternative pathway complement activation proteins, C3 and factor B, in the brains of mice with Listeria monocytogenes meningitis. Complement protein levels were found elevated in the cerebrospinal fluid of infected mice, compared with mock-infected animals, In the course of the disease, enhancedCS and factor B mRNA expression was detected on pyramidal neurons andPurkinje cells within 6 hours, peaking at 12 hours and then graduallydecreasing by 72 hours after infection, In addition, leukocytes infiltrating the subarachnoid space, within 12 to 24 hours, expressed mRNA for C3 and factor B, The cellular infiltration increased dramatically up to 72 hours, Intraperitoneal injection of tumor necrosis factor (TNF)-alpha up-regulated C3 and factor B mRNA expression on neurons in normal mice, suggesting that TNF-alpha may represent one cytokine regulating complement expression in this model of bacterial meningitis, However, additional mediators may be involved in regulation of intrathecalcomplement expression, as infected mice deficient of TNF/lympkotoxin-alpha genes bid not demonstrate attenuated complement expression in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:56:47