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Titolo:
THE TETRATRICOPEPTIDE REPEAT CONTAINING TG737 GENE IS A LIVER NEOPLASIA TUMOR-SUPPRESSOR GENE
Autore:
ISFORT RJ; CODY DB; DOERSEN CJ; RICHARDS WG; YODER BK; WILKINSON JE; KIER LD; JIRTLE RL; ISENBERG JS; KLOUNIG JE; WOYCHIK RP;
Indirizzi:
PROCTER & GAMBLE CO,MIAMI VALLEY LABS,POB 398707 CINCINNATI OH 45247 OAK RIDGE NATL LAB,DIV BIOL OAK RIDGE TN 37831 UNIV TENNESSEE,SCH VET MED KNOXVILLE TN 00000 MONSANTO AGR CO ST LOUIS MO 00000 DUKE UNIV,MED CTR DURHAM NC 00000 INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL INDIANAPOLIS IN 46202
Titolo Testata:
Oncogene
fascicolo: 15, volume: 15, anno: 1997,
pagine: 1797 - 1803
SICI:
0950-9232(1997)15:15<1797:TTRCTG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; STEM-CELLS; HUMAN HOMOLOG; SNAP HELIX; GROWTH; PROTEIN; DIFFERENTIATION; MUTATION; MOUSE; CARCINOGENESIS;
Keywords:
TG737; TUMOR SUPPRESSOR GENE; LIVER NEOPLASIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Isfort et al., "THE TETRATRICOPEPTIDE REPEAT CONTAINING TG737 GENE IS A LIVER NEOPLASIA TUMOR-SUPPRESSOR GENE", Oncogene, 15(15), 1997, pp. 1797-1803

Abstract

The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreatic human tumor cell lines. Ectopic re-expression of the Tg737 gene in a Tg737 deleted mouse liver tumor cell line resulted in suppression of tumorigenic growth, without altering in vitro cell culture growth. Treatment of mice which are either homozygous normal or heterozygous deleted at the Tg737 locus with the carcinogen diethylnitrosamine resulted in an increase in preneoplastic foci formation in the Tg737 heterozygous deleted mice. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. We believethis is the first report demonstrating tumor suppression activity fora tetratricopeptide repeat gene family member and provides insights into the function of this family of genes in mammalian cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:07:25