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Titolo:
INFERIOR COLLICULAR SEIZURE GENERALIZATION PRODUCES SITE-SELECTIVE CORTICAL INDUCTION OF CYCLOOXYGENASE-2 (COX-2)
Autore:
MCCOWN TJ; KNAPP DJ; CREWS FT;
Indirizzi:
UNIV N CAROLINA,BOWLES CTR ALCOHOL STUDIES,CB 7178,3033 THURSTON BOWLES CHAPEL HILL NC 27599 UNIV N CAROLINA,CTR NEUROSCI CHAPEL HILL NC 27599 UNIV N CAROLINA,GENE THERAPY CTR CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT PHARMACOL CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT PSYCHIAT CHAPEL HILL NC 27599
Titolo Testata:
Brain research
fascicolo: 2, volume: 767, anno: 1997,
pagine: 370 - 374
SICI:
0006-8993(1997)767:2<370:ICSGPS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCIBLE CYCLOOXYGENASE; RAT-BRAIN; GENESIS; EXPRESSION; CORTEX;
Keywords:
CYCLOOXYGENASE; INFERIOR COLLICULUS; SEIZURE; IMMEDIATE-EARLY GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Mccown et al., "INFERIOR COLLICULAR SEIZURE GENERALIZATION PRODUCES SITE-SELECTIVE CORTICAL INDUCTION OF CYCLOOXYGENASE-2 (COX-2)", Brain research, 767(2), 1997, pp. 370-374

Abstract

Given the potential role of mitogen-inducible cyclooxygenase (COX-2) in CNS damage, patterns of COX-2 induction were determined both beforeand after seizure generalization from the inferior collicular cortex into the forebrain, With midbrain seizures, no change was found in COX-2-like immunoreactivity, even at the site of seizure genesis. However, upon forebrain seizure generalization, dramatic, ipsilateral increases in COX-2-like immunoreactivity were found in layers II and UT of perirhinal, entorhinal and temporal cortex, just dorsal to the perirhinal fissure, coursing from the level of the medial geniculate to the level of the inferior colliculus. No changes in COX-2-like immunoreactivity were found in contralateral cortical regions, retrosplenial cortex,dentate gyrus, subiculum, tenia tectum or inferior colliculus. Thus, initial seizure generalization into the forebrain induces COX-2 expression in a highly specific area of the cerebral cortex, (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 09:26:55