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Titolo:
DOPAMINE-ADENOSINE INTERACTIONS IN THE STRIATUM AND THE GLOBUS-PALLIDUS - INHIBITION OF STRIATOPALLIDAL NEURONS THROUGH EITHER D-2A RECEPTORS ENHANCES D-2 RECEPTOR-MEDIATED EFFECTS ON C-FOS EXPRESSION
Autore:
LEMOINE C; SVENNINGSSON P; FREDHOLM BB; BLOCH B;
Indirizzi:
UNIV BORDEAUX 2,CNRS,INST FEDERATIF RECH NEUROSCI CLIN & EXPT,UNITE MIXTE RECH 5541 F-33076 BORDEAUX FRANCE KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,SECT MOL NEUROPHARMACOL S-17177 STOCKHOLM SWEDEN
Titolo Testata:
The Journal of neuroscience
fascicolo: 20, volume: 17, anno: 1997,
pagine: 8038 - 8048
SICI:
0270-6474(1997)17:20<8038:DIITSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGULATED GENE-EXPRESSION; MESSENGER-RNA EXPRESSION; RAT STRIATUM; BASAL GANGLIA; D2-DOPAMINE RECEPTORS; MOLECULAR-CLONING; NUCLEUS-ACCUMBENS; GABA RELEASE; D2 AGONIST; D1;
Keywords:
IN SITU HYBRIDIZATION; PHENOTYPICAL CHARACTERIZATION; IMMEDIATE EARLY GENE; DOPAMINE-ADENOSINE INTERACTIONS; SYNERGISTIC EFFECTS; STRIATAL OUTPUT PATHWAYS; GLOBUS PALLIDUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
C. Lemoine et al., "DOPAMINE-ADENOSINE INTERACTIONS IN THE STRIATUM AND THE GLOBUS-PALLIDUS - INHIBITION OF STRIATOPALLIDAL NEURONS THROUGH EITHER D-2A RECEPTORS ENHANCES D-2 RECEPTOR-MEDIATED EFFECTS ON C-FOS EXPRESSION", The Journal of neuroscience, 17(20), 1997, pp. 8038-8048

Abstract

D-1 receptors located on striatonigral neurons and D-2 receptors located, together with A(2A) receptors, on striatopallidal neurons are known to interact functionally. Using in situ hybridization, we examined the effects of D-1 and D-2 agonists and of an A(2A) antagonist on c-fos mRNA in identified striatal neurons and in globus pallidus. The fullD-1 agonist, SKF 82958 (1 mg/kg), induced a homogenous increase of c-fos mRNA in the striatum. This increase occurred to a similar extent in D-1 and D-2 receptor-containing striatal neurons. Conversely, the D-2 agonist, quinelorane (2 mg/kg), decreased c-fos mRNA in these populations but increased it in globus pallidus. The adenosine A(2A) receptor antagonist, SCH 58261 (5 mg/kg), also decreased c-fos mRNA in D-2 receptor-containing neurons in striatum but did not affect pallidal c-fos mRNA. Concomitant administration of either D-1 plus D-2 agonists or D-1 agonist plus A(2A) antagonist caused a potentiation of c-fos mRNA in striatal neurons expressing the D-1 receptor and in globus pallidus. However, only the combination of D-1 and D-2 agonists modified the c-fos mRNA expression to a ''patchy'' distribution, Our data show that (1) c-fos expression can be activated through D-1 and inhibited through A(2A) or D-2 receptors in both striatal output pathways in normal rats, and (2) D-2 receptor stimulation as well as A(2A) receptor blockade can interact with D-1 receptor activation to potentiate c-fos expression in the striatum and the globus pallidus. The data also suggest that the topological alteration of c-fos expression after coadministration of D-1 and D-2 agonists involves D-2 receptors located on interneurons or presynaptically on dopaminergic nerve terminals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:52:46