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Titolo:
QUANTITATIVE STUDIES OF CHICKEN SOMATOTROPHS DURING GROWTH AND DEVELOPMENT BY MORPHOMETRY, IMMUNOCYTOCHEMISTRY, AND FLOW-CYTOMETRY
Autore:
MALAMED S; DEAVER D; PEREZ F; RADECKI S; GIBNEY J; SCANES CG;
Indirizzi:
UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL,675 HOES LANE PISCATAWAY NJ 08854 PENN STATE UNIV,DEPT DAIRY & ANIM SCI,DAIRY BREEDING RES CTR UNIVERSITY PK PA 16802 RUTGERS STATE UNIV,DEPT ANIM SCI NEW BRUNSWICK NJ 08903
Titolo Testata:
General and comparative endocrinology
fascicolo: 1, volume: 108, anno: 1997,
pagine: 25 - 34
SICI:
0016-6480(1997)108:1<25:QSOCSD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE MESSENGER-RNA; AGE-RELATED-CHANGES; DOMESTIC-FOWL; FUNCTIONAL-DIFFERENTIATION; ANTERIOR-PITUITARY; SECRETION; PROLACTIN; GRANULES; GLAND; CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Malamed et al., "QUANTITATIVE STUDIES OF CHICKEN SOMATOTROPHS DURING GROWTH AND DEVELOPMENT BY MORPHOMETRY, IMMUNOCYTOCHEMISTRY, AND FLOW-CYTOMETRY", General and comparative endocrinology, 108(1), 1997, pp. 25-34

Abstract

Changes in the male chicken somatotroph during growth and maturation have been examined by morphometric and immunocytochemical (ICC) analysis of serial sections of the anterior pituitary gland and by flow cytometry of dispersed anterior pituitary cells. ICC showed that somatotrophs are confined to the middle and caudal thirds of the anterior pituitary gland at all ages from 5 to 26 weeks. At a given age somatotrophsare of equal size at all positions along the cephalocaudal axis of the anterior pituitary gland. However, there are age-related changes: from 5 to 11 weeks rises occur in both the mean total somatotroph volumeper gland (64%) and the mean number of somatotrophs (78%), while the mean volume of the single somatotroph is unchanged. From 11 to 18 weeks the mean volume of the single somatotroph decreases 41%. From 18 to 26 weeks the mean volume of the somatotroph, the mean total somatotroph volume, and the mean number per gland do not change. Flow cytometry studies suggested that somatotrophs from adults have less growth hormone (GH) than somatotrophs from young birds. The increases in total somatotroph volume and number from 5 to 11 weeks are consistent with the rise in anterior pituitary GH reported previously. Basic quantitative morphological information about age-related changes in somatotrophs isreported here. When combined with additional facts from future work, they may explain the well documented sharp decline in circulating GH from 5 to 11 weeks. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:40:10