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Titolo:
LIDOCAINE DOES NOT DEPRESS REFLEX DILATION OF THE PUPIL
Autore:
LARSON MD; KURZ A; SESSLER DI; DECHERT M; TAYEFEH F; BJORKSTEN AR;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIA,521 PARNASSUS AVE,ROOM C450,BOX 0648 SAN FRANCISCO CA 94143
Titolo Testata:
Regional anesthesia
fascicolo: 5, volume: 22, anno: 1997,
pagine: 461 - 465
SICI:
0146-521X(1997)22:5<461:LDNDRD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL-ANESTHETIC AGENTS; ELECTRICAL-STIMULATION; LIGNOCAINE; RESPONSES; NERVE; RAT;
Keywords:
PUPIL SIZE; REFLEX DILATION; DESFLURANE LIDOCAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Larson et al., "LIDOCAINE DOES NOT DEPRESS REFLEX DILATION OF THE PUPIL", Regional anesthesia, 22(5), 1997, pp. 461-465

Abstract

Background and Objectives. Pupillary dilation in response to dermatomal electrical stimulation is one method of determining sensory block level during combined epidural and general anesthesia. Use of this technique may, however, be confounded by systemic absorption of epidurallyadministered local anesthetics. Accordingly, the effects of intravenous lidocaine on the magnitude and duration of reflex pupillary dilation were evaluated. Methods. Six volunteers were each anesthetized twicewith desflurane 3.5-6.0%. During one anesthetic, intravenous lidocaine was administered to a plasma concentration of 5.3 +/- 1.5 mu g/mL. When the plasma concentrations were stable, a 5-second tetanic electrical stimulus was applied. Pupil size was then recorded for 8 minutes. Results. Lidocaine, at plasma concentrations near 5 mu g/mL, did not significantly alter the pupillary response to electrical stimulation In contrast, stimulus-induced increase in heart rate was obliterated. Painful stimulation did not increase systolic blood pressure in either case. Conclusions. Typical plasma lidocaine concentrations observed during epidural anesthesia are unlikely to prevent the use of pupillary responses to evaluate sensory block level.

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Documento generato il 14/07/20 alle ore 10:57:18