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Titolo:
SKELETAL-MUSCLE FUNCTION AT LOW WORK LEVEL AS A MODEL FOR DAILY ACTIVITIES IN PATIENTS WITH CHRONIC HEART-FAILURE
Autore:
OPASICH C; PASINI E; AQUILANI R; COBELLI F; SOLFRINI R; FERRARI R; TAVAZZI L;
Indirizzi:
V MONTESCANO I-27040 MONTESCANO PV ITALY FDN S MAUGERI,INST CARE & RES,HEART FAILURE UNIT MONTESCANO PV ITALY OPERA PIA P RICHIEDEI,CLIN LAB GUSSAGO BS ITALY CARDIOVASC RES CTR GUSSAGO ITALY
Titolo Testata:
European heart journal
fascicolo: 10, volume: 18, anno: 1997,
pagine: 1626 - 1631
SICI:
0195-668X(1997)18:10<1626:SFALWL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; EXERCISE CAPACITY; BLOOD-FLOW; METABOLIC ABNORMALITIES; LEG MUSCLE; FATIGUE; HEMODYNAMICS; SPECTROSCOPY; LIMITATION; LACTATE;
Keywords:
CHRONIC HEART FAILURE; PERIPHERAL METABOLISM; DAILY LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C. Opasich et al., "SKELETAL-MUSCLE FUNCTION AT LOW WORK LEVEL AS A MODEL FOR DAILY ACTIVITIES IN PATIENTS WITH CHRONIC HEART-FAILURE", European heart journal, 18(10), 1997, pp. 1626-1631

Abstract

Aim Metabolic exercise abnormalities have been reported in chronic heart failure patients. This study sought to evaluate whether these abnormalities affected daily activity. Methods and results In 16 patients with moderate-to-severe chronic heart failure and in eight controls wemeasured femoral flow (thermodilution) and metabolism (glucose, lactate, free fatty acids, blood gas values) at rest and during a constant load of 20 W, which may mimic a daily activity. At rest, chronic heartfailure patients had a leg flow similar to controls, but showed a higher leg oxygen consumption (4.6 +/- 0.6 vs 2.6 +/- 0.4 ml.min(-1); P<0.05), a higher arteriovenous oxygen difference (7.2 +/- 0.5 vs 5.4 +/-0.7 ml.dl(-1): P<0.05), and a lower femoral vein pH (7.37 +/- 5.-03 vs 7.42 +/- 0.01: P=0.01). At 20 W, chronic heart failure patients had a leg flow similar to controls, but showed increased lactate release (from resting 11.7 +/- 33 to 142 +/- 125 mu g.min(-1) P<0.0001 vs controls, from resting 5.7 +/- 15.4 to 50 +/- 149 mu g.min(-1) ns), higher arterial concentration of free fatty acids (781 +/- 69 vs 481 +/- 85 mu mol.1(-1): P<0.01), lower femoral vein HCO3 (24.1 +/- 2.6 vs 26.3 +/- 1.7 mmol.1(-1); P<0.05) and base excess (-2.3 +/- 2.3 vs -0.24 +/- 1.7 mmol.1(-1); P=0.01). Conclusion In chronic heart failure patients, the important cellular metabolic alterations already present at rest partially affect daily activities, owing to a further decrease in the efficiency of muscle metabolic processes, and may preclude tolerance ofheavier activities. Such alterations appear, at least in part, independent of peripheral haemodynamic responses to exercise.

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Documento generato il 03/07/20 alle ore 01:07:33