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Titolo:
PROTON MRS AND QUANTITATIVE MRI ASSESSMENT OF THE SHORT-TERM NEUROLOGICAL RESPONSE TO ANTIRETROVIRAL THERAPY IN AIDS
Autore:
WILKINSON ID; LUNN S; MISZKIEL KA; MILLER RF; PALEY MNJ; WILLIAMS I; CHINN RJS; HALLCRAGGS MA; NEWMAN SP; KENDALL BE; HARRISON MJG;
Indirizzi:
UNIV COLL LONDON HOSP,MRI UNIT,MIDDLESEX HOSP,NHS TRUST,DEPT MED PHYS& BIOENGN,MORTIMER ST LONDON W1N 8AA ENGLAND UNIV COLL LONDON,SCH MED,DEPT PSYCHIAT LONDON W1N 8AA ENGLAND UNIV COLL LONDON HOSP,DEPT RADIOL,MIDDLESEX HOSP,NHS TRUST LONDON W1N8AA ENGLAND UNIV COLL LONDON,SCH MED,DIV PATHOL & INFECT DIS LONDON W1N 8AA ENGLAND UNIV COLL LONDON,SCH MED,DEPT NEUROL LONDON W1N 8AA ENGLAND
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 4, volume: 63, anno: 1997,
pagine: 477 - 482
SICI:
0022-3050(1997)63:4<477:PMAQMA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; HIV-SEROPOSITIVE INDIVIDUALS; NEURONAL LOSS; CEREBROSPINAL-FLUID; DEMENTIA COMPLEX; INFECTION; BRAIN; ZIDOVUDINE; DISEASE;
Keywords:
MAGNETIC RESONANCE SPECTROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS; ZIDOVUDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
I.D. Wilkinson et al., "PROTON MRS AND QUANTITATIVE MRI ASSESSMENT OF THE SHORT-TERM NEUROLOGICAL RESPONSE TO ANTIRETROVIRAL THERAPY IN AIDS", Journal of Neurology, Neurosurgery and Psychiatry, 63(4), 1997, pp. 477-482

Abstract

Objective-To investigate MRI and proton spectroscopy changes in five patients with HIV associated dementia complex (HADC) treated with antiretroviral therapy. Methods Three markers were evaluated: (1) CSF/intracranial volume ratio; (2) T2 weighted signal ratio between parietooccipital white and subcortical grey matter; and (3) metabolite ratios from long echo time (TE=135 ms) single voxel proton spectra of parieto-occipital white matter. Results-Spectroscopic changes indicated initialincreases in N-acetyl/(N-acetyl + choline + creatine) ratio (NA/(NA+ Cho+Cr)) and progression of atrophy after initiation of antiretroviraltherapy in four of five patients. When the neurological status of thepatients subsequently deteriorated (two of five patients), the NA/(NACho+Cr) ratio also declined. Conclusions-spectroscopic changes mirrorreversible neuronal dysfunction. These objective, non-invasive techniques may be used for monitoring the neurological effects of antiretroviral drug therapy in patients with HADC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:20:40