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Titolo:
MULTIPLE CHEMICAL-SENSITIVITY SYNDROME - A CLINICAL PERSPECTIVE .1. CASE-DEFINITION, THEORIES OF PATHOGENESIS, AND RESEARCH NEEDS
Autore:
SPARKS PJ; DANIELL W; BLACK DW; KIPEN HM; ALTMAN LC; SIMON GE; TERR AI;
Indirizzi:
PROVIDENCE MED CTR,BUSINESS HLTH SERV,1600 E JEFFERSON,SUITE 201 SEATTLE WA 98122 UNIV WASHINGTON,SCH MED,OCCUPAT MED PROGRAM SEATTLE WA 98195 UMDNJ,ROBERT WOOD JOHNSON MED SCH,INST ENVIRONM & OCCUPAT HLTH SCI PISCATAWAY NJ 00000 CTR HLTH STUDIES,HLTH COOPERAT PUGET SOUND SEATTLE WA 00000 STANFORD SCH MED,DEPT MED,DIV IMMUNOL STANFORD CA 00000 UNIV IOWA HOSP & CLIN,DEPT PSYCHIAT ADM IOWA CITY IA 52242 UNIV WASHINGTON,SCH MED,DEPT ENVIRONM HLTH,DIV ALLERGY & INFECT DIS SEATTLE WA 98195
Titolo Testata:
Journal of occupational medicine
fascicolo: 7, volume: 36, anno: 1994,
pagine: 718 - 730
SICI:
0096-1736(
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; CHRONIC FATIGUE SYNDROME; SELF-REPORTED ILLNESS; ENVIRONMENTAL ILLNESS; 20TH-CENTURY DISEASE; PSYCHIATRIC DIAGNOSES; ORGANIC-SOLVENTS; TOTAL ALLERGY; NASAL-MUCOSA; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Sparks et al., "MULTIPLE CHEMICAL-SENSITIVITY SYNDROME - A CLINICAL PERSPECTIVE .1. CASE-DEFINITION, THEORIES OF PATHOGENESIS, AND RESEARCH NEEDS", Journal of occupational medicine, 36(7), 1994, pp. 718-730

Abstract

Multiple chemical sensitivity syndrome (MCS) does not appear to fit established principles of toxicology. Yet social, political, and economic forces are demanding that MCS be defined medically, even though to date scientific studies have not identified pathogenic mechanisms for the condition or any objective diagnostic criteria. Consequently, a working definition of MCS can rely only on an individual's subjective symptoms of distress and attribution to environmental exposures rather than currently measurable objective evidence of disease. Nevertheless, patients labeled with MCS are clearly distressed and many are functionally disabled. In this review, four theories of causation are explored; (1) MCS is a purely biologic/physical or psychophysiologic reaction to low-level chemical exposures. (2) MCS symptoms may be elicited by low-level environmental chemical exposures, but the sensitivity is initiated by psychologic stress. (3) MCS is a misdiagnosis and chemical exposure is not the cause. The symptoms may be due to misdiagnosed physical or psychologic illness. (4) MCS is an illness belief system manifest by culturally shaped illness behavior. Areas for further research regarding the etiologies of MCS are suggested. Recognizing that the cause of the syndrome may be multifactorial, strategies are proposed for clinical evaluation and management in Part II of this manuscript usinga biopsychosocial model of illness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:36:03