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Titolo:
EFFECTS OF IN-UTERO AND LACTATIONAL EXPOSURE OF THE LABORATORY RAT TO2,4,2',4'-TETRACHLOROBIPHENYL AND 3,4,3',4'-TETRACHLOROBIPHENYL ON DOPAMINE FUNCTION
Autore:
SEEGAL RF; BROSCH KO; OKONIEWSKI RJ;
Indirizzi:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,BOX 509 ALBANY NY 12201 SUNY ALBANY,SCH PUBL HLTH ALBANY NY 12201
Titolo Testata:
Toxicology and applied pharmacology
fascicolo: 1, volume: 146, anno: 1997,
pagine: 95 - 103
SICI:
0041-008X(1997)146:1<95:EOIALE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED POLYCHLORINATED-BIPHENYLS; TYROSINE-HYDROXYLASE ACTIVITY; CHRONIC ESTRADIOL TREATMENT; CENTRAL NERVOUS-SYSTEM; DISCRETE BRAIN NUCLEI; PREFRONTAL CORTEX; STRIATAL DOPAMINE; IN-VIVO; CATECHOLAMINERGIC NEURONS; BIOGENIC-AMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Seegal et al., "EFFECTS OF IN-UTERO AND LACTATIONAL EXPOSURE OF THE LABORATORY RAT TO2,4,2',4'-TETRACHLOROBIPHENYL AND 3,4,3',4'-TETRACHLOROBIPHENYL ON DOPAMINE FUNCTION", Toxicology and applied pharmacology, 146(1), 1997, pp. 95-103

Abstract

Offspring of Sprague-Dawley derived dams were exposed to either 2,4,2',4'-tetrachlorobiphenyl (TCB) (1, 10, or 20 mg/(kg.day)) or 3,4,3',4'-TCB (0.1 or 1 mg/(kg.day)) from gestational Day 6 through weaning by providing the dams with cookies adulterated with the appropriate amount and type of PCB. Male and female offspring were sacrificed on postnatal Days 35, 60, and 90, and brain concentrations of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, were determined in the frontal cortex, caudate nucleus and substantia nigra by high-performance liquid chromatography with electrochemical detection. In utero and lactational exposure to 3,4,3',4'-TCB resulted in significant elevations in concentrations of dopamine in the frontal cortex, and of dopamine and its metabolites in the substantia nigra thatpersisted into adulthood. In contrast, in utero and lactational exposure to 2,4,2',4'-TCB resulted in significant decreases in concentrations of dopamine in the frontal cortex and caudate nucleus that also persisted into adulthood. We suggest that the reductions in brain dopamine concentrations are a consequence of ortho-substituted PCB congener-induced inhibition of the synthesis of dopamine during critical periodsof development acting, perhaps, in concert with PCB-induced changes in cholinergic receptor function. On the other hand, the persistent elevations in brain dopamine and metabolite concentrations following perinatal exposure to 3,4,3',4'-TCB may be mediated by alterations in steroid hormone function during key developmental periods. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:43:59