Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HEXOSAMINIDASE IN TRICHINELLA-SPIRALIS IS A SINGLE PROTEIN WITH ALPHA-SUBUNIT AND BETA-SUBUNIT CATALYTIC ACTIVITIES
Autore:
COSTANZI E; BECCARI T; DELLAFAZIA MA; SERVILLO G; ORLACCHIO A; TASSI C; BRUSCHI F;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOL,SEZ BIOCHIM & BIOL MOL,VIA GIOCHETTO I-06126 PERUGIA ITALY UNIV PERUGIA,MONTELUCE POLICLIN,IST PATOL GEN I-06126 PERUGIA ITALY UNIV PERUGIA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,SEZ MED LAB I-06126 PERUGIA ITALY UNIV PARIS 05,LAB BIOCHIM & GLYCOBIOL,UFR SCI PHARMACEUT & BIOL F-75006 PARIS FRANCE
Titolo Testata:
Cellular and molecular biology
fascicolo: 6, volume: 43, anno: 1997,
pagine: 835 - 840
SICI:
0145-5680(1997)43:6<835:HITIAS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ACETYLHEXOSAMINIDASE-A; SEQUENCE-ANALYSIS; HUMAN ENZYME; CDNA; CLONING; HOMOLOGY; ACETYLGLUCOSAMINIDASE; ACID; GENE;
Keywords:
HEXOSAMINIDASE; LYSOSOME; TRICHINELLA SPIRALIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E. Costanzi et al., "HEXOSAMINIDASE IN TRICHINELLA-SPIRALIS IS A SINGLE PROTEIN WITH ALPHA-SUBUNIT AND BETA-SUBUNIT CATALYTIC ACTIVITIES", Cellular and molecular biology, 43(6), 1997, pp. 835-840

Abstract

beta-N-acetylhexosaminidase is expressed as a single protein in Trichinella spiralis and has catalytic properties similar to the alpha- andbeta-subunits of human and mouse isoenzymes A and B. It can hydrolyzethe artificial substrates, 4-methylumbelliferyl-beta-D-glucosamine and 4-methylumbelliferyl-beta-D-glucosamine-6-sulphate which are respectively hydrolyzed by the beta- and alpha-subunits. The enzyme is thermostable, has a basic isoelectric point, and thus is similar to the B isoenzyme. Northern blotting experiments indicate that the enzyme is encoded by a single gene. Hexosaminidase from Trichinella spiralis shows that the substrate specificities of alpha- and beta-subunits precede the duplication of their genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:40:42