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Titolo:
PRESERVED ENDOTHELIAL FUNCTION AND MORPHOLOGY IN CANINE ARTERIAL GRAFTS UNDER CONDITIONS OF POOR DISTAL RUNOFF
Autore:
WEI CG; KOMORI K; MAWATARI K; YONEMITSU Y; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT SURG 2 FUKUOKA 812 JAPAN
Titolo Testata:
The Journal of surgical research
fascicolo: 2, volume: 71, anno: 1997,
pagine: 117 - 122
SICI:
0022-4804(1997)71:2<117:PEFAMI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL-MAMMARY-ARTERY; AUTOGENOUS VEIN GRAFTS; VASCULAR SMOOTH-MUSCLE; SAPHENOUS-VEIN; BYPASS GRAFTS; PLATELET-AGGREGATION; INTIMAL HYPERPLASIA; RESPONSES; DOG; CIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
C.G. Wei et al., "PRESERVED ENDOTHELIAL FUNCTION AND MORPHOLOGY IN CANINE ARTERIAL GRAFTS UNDER CONDITIONS OF POOR DISTAL RUNOFF", The Journal of surgical research, 71(2), 1997, pp. 117-122

Abstract

Late graft failure is still a significant problem particularly in vessels with poor runoff, In the present study, we examined whether poor runoff conditions contributed to either functional or morphological changes in experimental canine autogenous arterial grafts. Four weeks after grafting, isometric tension studies were performed on rings obtained from femoral arterial grafts with poor runoff and the findings werecompared to rings from grafts with normal runoff. The flow rate and tau variation (wall shear stress variation) ire the limbs with poor runoff (18.5 +/- 4.2 ml/min, 52.9 +/- 7.0 dyne/cm(2)) were significantly lower than those of the control limb (66.4 +/- 9.2 ml/min, 201.1 +/- 9.6 dyne/cm(2)). Acetylcholine (ACh), adenosine 5'-diphosphate (ADP), and A23187 (calcium ionophore) caused comparable endothelium-dependent relaxations in the two groups. Smooth muscle relaxation in response tosodium nitroprusside was also comparable in the two groups. No apparent intimal thickening of the arterial grafts was observed in the canine arterial grafts with normal or poor runoff. Scanning electron microscopy demonstrated mild endothelial cell damage in implanted autogenousarterial grafts. At 7 to 14 days after grafting, the endothelial celllayer in both groups of grafts appeared to be normal. These results are markedly different from our previous findings with vein grafts in which pronounced intimal thickening was associated with an impairment of the endothelium-dependent responses under conditions of poor runoff. Based on these findings, the intact endothelial function and the absence of intimal thickening under conditions of poor runoff may thus explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization. (C) 1997 academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:35:19