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Titolo:
INCREASES IN MESSENGER-RNA LEVELS OF GLUCOSE TRANSPORTERS TYPE-1 AND TYPE-3 IN EHRLICH ASCITES TUMOR-CELLS DURING TUMOR-DEVELOPMENT
Autore:
AU KK; LIONG E; LI JY; LI PS; LIEW CC; KWOK TT; CHOY YM; LEE CY; FUNG KP;
Indirizzi:
CHINESE UNIV HONG KONG,DEPT BIOCHEM SHATIN NT HONG KONG CHINESE UNIV HONG KONG,DEPT BIOCHEM SHATIN NT HONG KONG UNIV TORONTO,DEPT CLIN BIOCHEM TORONTO ON CANADA
Titolo Testata:
Journal of cellular biochemistry
fascicolo: 1, volume: 67, anno: 1997,
pagine: 131 - 135
SICI:
0730-2312(1997)67:1<131:IIMLOG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN-TUMORS; GENE-EXPRESSION; HUMAN CANCER; IN-VITRO; GLUT3; METHOTREXATE; ERYTHROCYTE; ISOFORMS; FAMILY;
Keywords:
EHRLICH ASCITES TUMOR; GLUCOSE TRANSPORTER; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Au et al., "INCREASES IN MESSENGER-RNA LEVELS OF GLUCOSE TRANSPORTERS TYPE-1 AND TYPE-3 IN EHRLICH ASCITES TUMOR-CELLS DURING TUMOR-DEVELOPMENT", Journal of cellular biochemistry, 67(1), 1997, pp. 131-135

Abstract

A common feature of many tumors is an increase in glucose catabolism during tumor growth. We studied the mechanism of this phenomenon by using Ehrlich ascites tumor bearing mice as the animal model. We found that Ehrlich ascites tumor ce Is possess only glucose transporter 1 (GLUT1) and GLUT3 but no GLUT2, GLUT4, or GLUT5. The mRNA levels of GLUT1and GLUT3 increased progressively in the tumour during development; however, there were no changes observable in mRNA levels of glucose transporters of all types in brain, liver, and heart of the host mice. These findings suggest that Ehrlich ascites tumor augments its glucose transport mechanism relative to other tissues in response to its uniquegrowth needs. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 07:58:18