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Titolo:
SURVIVAL-PROMOTING ACTIVITY OF INHIBITORS OF CYCLIN-DEPENDENT KINASESON PRIMARY NEURONS CORRELATES WITH INHIBITION OF C-JUN KINASE-1
Autore:
MARKUS MA; KAHLE PJ; WINKLER A; HORSTMANN S; ANNESER JMH; BORASIO GD;
Indirizzi:
UNIV MUNICH,DEPT NEUROL,KLINIKUM GROSSHADERN D-81366 MUNICH GERMANY UNIV MUNICH,DEPT NEUROL,KLINIKUM GROSSHADERN D-81366 MUNICH GERMANY STANFORD UNIV,SCH MED,DEPT NEUROBIOL STANFORD CA 94305
Titolo Testata:
Neurobiology of disease
fascicolo: 2, volume: 4, anno: 1997,
pagine: 122 - 133
SICI:
0969-9961(1997)4:2<122:SAOIOC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; PROGRAMMED CELL-DEATH; SYMPATHETIC NEURONS; PC12 CELLS; NEUROTROPHIC FACTOR; GENE-EXPRESSION; PROTEIN; D1; DIFFERENTIATION; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Markus et al., "SURVIVAL-PROMOTING ACTIVITY OF INHIBITORS OF CYCLIN-DEPENDENT KINASESON PRIMARY NEURONS CORRELATES WITH INHIBITION OF C-JUN KINASE-1", Neurobiology of disease, 4(2), 1997, pp. 122-133

Abstract

Cyclin-dependent kinases and mitogen-activated protein kinases have been implicated in the regulation of cellular survival and apoptosis. We tested the effect of two mitogen-activated/cyclin-dependent kinase inhibitors, olomoucine and butyrolactone I, on the in vitro survival ofchick embryonic neurons. Sensory, sympathetic, and ciliary neurons, when prepared at their respective time point of programmed cell death, could be rescued from apoptosis by both inhibitors in a dose-dependentfashion. In contrast, dividing sympathetic precursors underwent apoptosis when treated with olomoucine, but not butyrolactone I, at the same range of concentration. With similar potency, olomoucine and butyrolactone I inhibited immunocomplex c-Jun kinase activity. Both substances inhibited neurite outgrowth in a dose-dependent manner; developmentally younger neurons were more sensitive to this effect than older ones. These results suggest that certain mitogen-activated/cyclin-dependent kinases associated with cell division in neuronal precursors (i) maybecome essential components of the apoptotic machinery by the time neurons reach their phase of naturally occurring cell death and (ii) maybe necessary for neurite outgrowth during development. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:10:30