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Titolo:
REQUIREMENT OF CELL-CELL CONTACT IN THE INDUCTION OF JURKAT T-CELL APOPTOSIS - THE MEMBRANE-ANCHORED BUT NOT SOLUBLE FORM OF FASL CAN TRIGGER ANTI-CD3-INDUCED APOPTOSIS IN JURKAT T-CELLS
Autore:
OYAIZU N; KAYAGAKI N; YAGITA H; PAHWA S; IKAWA Y;
Indirizzi:
TOKYO MED & DENT UNIV,DEPT RETROVIRAL REGULAT,DIV MED RES,BUNKYO KU,ROOM 665,1-5-45 YUSHIMA TOKYO 113 JAPAN JUNTENDO UNIV,SCH MED,DEPT IMMUNOL TOKYO 113 JAPAN NYU,SCH MED,N SHORE UNIV HOSP,DEPT PEDIAT MANHASSET NY 11030
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 238, anno: 1997,
pagine: 670 - 675
SICI:
0006-291X(1997)238:2<670:ROCCIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN-LYMPHOCYTES; LIGAND; RECEPTOR; ANTIGEN; ACTIVATION; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
N. Oyaizu et al., "REQUIREMENT OF CELL-CELL CONTACT IN THE INDUCTION OF JURKAT T-CELL APOPTOSIS - THE MEMBRANE-ANCHORED BUT NOT SOLUBLE FORM OF FASL CAN TRIGGER ANTI-CD3-INDUCED APOPTOSIS IN JURKAT T-CELLS", Biochemical and biophysical research communications, 238(2), 1997, pp. 670-675

Abstract

Fas ligand (Fast) has been shown to be processed by the action of certain metalloproteinase and released from the cell surface, However, itis unclear whether death of Fas-sensitive target cells is mediated bya membrane-bound form of Fast (mFasL) or by a soluble form of Fast (sFasL), In the present study, we demonstrated that JCaM, a p56lck-deficient mutant of Jurkat, underwent Fas dependent apoptosis only upon physical contact with anti-CD3-stimulated Jurkat cells or with human Fast-expressing transfectant (hFas/L5178Y). Recombinant Fast or sFasL-containing supernatant failed to induce apoptosis in both Jurkat and JCaM. Moreover, addition of a metalloproteinase inhibitor, which led to theaccumulation of mFasL in hFas/L5178Y, was found to augment apoptosis in both Jurkat and JCaM. These findings indicate that, in a physiologic setting represented by the activation-induced cell death in Jurkat Tcells, cell-cell contact appears to be required for the induction of Fas-mediated killing. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:05:18