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Titolo: ACCUMULATION OF ARMADILLO INDUCED BY WINGLESS, DISHEVELLED, AND DOMINANT-NEGATIVE ZESTE-WHITE-3 LEADS TO ELEVATED DE-CADHERIN IN DROSOPHILACLONE-8 WING DISC CELLS
Autore: YANAGAWA SI; LEE JS; HARUNA T; ODA H; UEMURA T; TAKEICHI M; ISHIMOTO A;
- Indirizzi:
- KYOTO UNIV,INST VIRUS RES,DEPT VIRAL ONCOL,SAKYO KU KYOTO 606 JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,SAKYO KU KYOTO 606 JAPAN
- Titolo Testata:
- The Journal of biological chemistry
fascicolo: 40,
volume: 272,
anno: 1997,
pagine: 25243 - 25251
- SICI:
- 0021-9258(1997)272:40<25243:AOAIBW>2.0.ZU;2-0
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- SEGMENT-POLARITY GENE; GLYCOGEN-SYNTHASE KINASE-3; TUMOR-SUPPRESSOR PROTEIN; BETA-CATENIN; XENOPUS EMBRYOS; SIGNALING PATHWAY; INT-1 PROTOONCOGENE; CYTOPLASMIC DOMAIN; ADHERENS JUNCTION; LIMB DEVELOPMENT;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 81
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- S.I. Yanagawa et al., "ACCUMULATION OF ARMADILLO INDUCED BY WINGLESS, DISHEVELLED, AND DOMINANT-NEGATIVE ZESTE-WHITE-3 LEADS TO ELEVATED DE-CADHERIN IN DROSOPHILACLONE-8 WING DISC CELLS", The Journal of biological chemistry, 272(40), 1997, pp. 25243-25251
Abstract
Drosophila genetic studies suggest that in the Wingless (Wg) signaling pathway, the segment polarity gene products, Dishevelled (Dsh), Zeste-white 3 (ZW-3), and Armadillo (Arm), work sequentially; wg and dsh negatively regulate zw-3, which in turn down-regulates arm. To biochemically analyze interactions between the Wg pathway and Drosophila E-cadherin (DE-cadherin) which bind to Arm, we overexpressed Dsh, ZW-3, andArm, in the Drosophila wing disc cell Line, clone 8, which responds to Wg signal. Dsh overexpression led to accumulation of Arm primarily in the cytosol and elevation of DE-cadherin at cell junctions. Overexpression of wildtype and dominant-negative forms of ZW-3 decreased and increased Arm levels, respectively, indicating that modulation in zw-3 activity negatively regulates Arm levels. Overexpression of an Arm mutant with an aminoterminal deletion elevated DE-cadherin levels, suggesting that Dsh-induced DE-cadherin elevation is caused by the Arm accumulation induced by Dsh. Moreover, the Dsh-, dominant-negative ZW-3-, and truncated Arm-induced accumulation of DE-cadherin protein was accompanied by a marked increase in the steady-state levels of DE-cadherin mRNA, suggesting that transcription of DE-cadherin is activated by Wg signaling. In addition, overexpression of DE-cadherin elevated Arm levels by stabilizing Arm at cell-cell junctions.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:42:08