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Titolo:
ACTIVITY LEVELS OF A BETA-1,6 N-ACETYLGLUCOSAMINYLTRANSFERASE IN LYMPHOMONOCYTES FROM MULTIPLE-SCLEROSIS PATIENTS
Autore:
ORLACCHIO A; SARCHIELLI P; GALLAI V; DATTI A; SACCARDI C; PALMERINI CA;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOL,VIA GIOCHETTO I-06126 PERUGIA ITALY UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOL I-06126 PERUGIA ITALY UNIV PERUGIA,IST NEUROPSICHIAT NEUROL I-06126 PERUGIA ITALY
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 151, anno: 1997,
pagine: 177 - 183
SICI:
0022-510X(1997)151:2<177:ALOABN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
WISKOTT-ALDRICH SYNDROME; CELL LINES; T-CELLS; LYMPHOCYTES; SERUM; IL-2; GLYCOSYLATION; BIOSYNTHESIS; EXPRESSION; SECRETION;
Keywords:
MULTIPLE SCLEROSIS; LYMPHOMONOCYTES; N-ACETYLGLUCOSAMINYLTRANSFERASE; ENZYME ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Orlacchio et al., "ACTIVITY LEVELS OF A BETA-1,6 N-ACETYLGLUCOSAMINYLTRANSFERASE IN LYMPHOMONOCYTES FROM MULTIPLE-SCLEROSIS PATIENTS", Journal of the neurological sciences, 151(2), 1997, pp. 177-183

Abstract

The activity of the Golgi glycosyltransferase beta 1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T), which plays a role in T-cell activation and cell-cell adhesion, appears to be modulated in resting lymphomonocytes during different phases of multiple sclerosis (MS). In particular, a significant decrease (25-30%) of the enzyme activity was observed, with respect to healthy subjects, in MS patients who were in relapse or in the Very early stages of remission. A similar trend was found to be associated with patients affected by active lesions. A statistically significant decrease in the enzyme activity was also observed in patients with the progressive form. By contrast, core 2 GlcNAc-T activity did not appear correlated with duration of the disease. Interestingly, MS individuals under treatment with IFN-beta 1a, an immunosuppressive agent, showed levels of activity which were comparable with those observed in healthy subjects. Together, these observations suggest that down-regulation of core 2 GlcNAc-T activity is linked to the occurrence of acute phases in the relapsing-remitting form and to the progressive form of the disease, probably caused by altered expression of glycoproteins which are involved in lymphomonocyte activation and/or interaction with the endothelium. Additionally, it appears that the enzyme assay may provide a useful marker of the disease activity and the effects of therapeutical approaches. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:06:01