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Titolo:
NITRIC-OXIDE IN THE CONTROL OF SUBMANDIBULAR SALIVARY-GLAND FUNCTION IN THE ANESTHETIZED FERRET
Autore:
TOBIN G; EDWARDS AV; BLOOM SR; EKSTROM J;
Indirizzi:
UNIV GOTHENBURG,DEPT PHARMACOL,MEDICINAREGATAN 7 S-41390 GOTHENBURG SWEDEN UNIV CAMBRIDGE,PHYSIOL LAB CAMBRIDGE CB2 3EG ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED LONDON W12 9DS ENGLAND
Titolo Testata:
Experimental physiology
fascicolo: 5, volume: 82, anno: 1997,
pagine: 825 - 836
SICI:
0958-0670(1997)82:5<825:NITCOS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; STIMULATES ADENYLATE-CYCLASE; AUTONOMIC NERVOUS-SYSTEM; PARASYMPATHETIC INNERVATION; ANESTHETIZED FERRET; PROTEIN SECRETION; IN-VIVO; PEPTIDE; CAT; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
G. Tobin et al., "NITRIC-OXIDE IN THE CONTROL OF SUBMANDIBULAR SALIVARY-GLAND FUNCTION IN THE ANESTHETIZED FERRET", Experimental physiology, 82(5), 1997, pp. 825-836

Abstract

Stimulation of the parasympathetic innervation of the submandibular gland (2 or 20 Hz continuously or 20 Hz for 1 s at 10 s intervals), in the ferret, produced secretion of fluid and protein and a fall in vascular resistance. The responses following the administration of N-omega-nitro-L-arginine methyl ester (L-NAME; 2 mmol kg(-1) I.A.) to block the synthesis of nitric oxide (NO) were reduced, and the persisting responses were abolished (at 2 Hz continuously and 20 Hz intermittently) or further reduced (at 20 Hz continuously) by the additional administration of atropine. The output of vasoactive intestinal peptide (VIP) from the gland was not affected. Neither the secretory nor the vascularresponse to intra-arterial infusions of acetylcholine (1.25 nmol kg(-1)) was affected by L-NAME, whereas the vascular responses to both VIP(10 pmol kg(-1)),, and pituitary adenylate cyclase-activating peptide(1-38) (PACAP) (0.5 pmol kg(-1)) were reduced thereby. Neither peptideevoked a fluid secretion per se. However, when infused during parasympathetic stimulation of saliva secretion, VIP increased both flow rareand the output of protein. These effects of VIP were abolished by L-NAME. The experiments were performed in the presence of sodium nitroprusside at doses (4-8 nmol min(-1) kg(-1) I.V.) aimed to counterbalance the systemic effects of L-NAME. The results show that, in the ferret, parasympathetic nerve activity increases submandibular blood flow, andelicits the flow of saliva and output of protein by mechanisms that involve in situ generation of NO, upon which the effects of VIP and PACAP but not acetylcholine are largely dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:10:13