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Titolo:
REDUCTION OF AGGRESSIVENESS AND IMPULSIVENESS DURING CLOZAPINE TREATMENT IN CHRONIC NEUROLEPTIC-RESISTANT SCHIZOPHRENIC-PATIENTS
Autore:
SPIVAK B; MESTER R; WITTENBERG N; MAMAN Z; WEIZMAN A;
Indirizzi:
NESS ZIONA MENTAL HLTH CTR,RES UNIT,POB 1 IL-74100 NESS ZIONA ISRAEL HEBREW UNIV JERUSALEM,FAC AGR JERUSALEM ISRAEL FELSENSTEIN MED RES CTR,LAB BIOL PSYCHIAT PETAH TIQWA ISRAEL GEHA PSYCHIAT HOSP,RES UNIT PETAH TIQWA ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Clinical neuropharmacology
fascicolo: 5, volume: 20, anno: 1997,
pagine: 442 - 446
SICI:
0362-5664(1997)20:5<442:ROAAID>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN; SCALE; BRAIN; RISK;
Keywords:
SCHIZOPHRENIA; AGGRESSION; IMPULSIVENESS; CLOZAPINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
B. Spivak et al., "REDUCTION OF AGGRESSIVENESS AND IMPULSIVENESS DURING CLOZAPINE TREATMENT IN CHRONIC NEUROLEPTIC-RESISTANT SCHIZOPHRENIC-PATIENTS", Clinical neuropharmacology, 20(5), 1997, pp. 442-446

Abstract

Aggressive and impulsive behavior is frequently observed in schizophrenic patients. Previous studies suggest that impulsive aggression may be the most common behavioral correlate of central serotonergic systemdysfunction. This study was aimed to determine if clozapine, an atypical antipsychotic agent with potent serotonergic antagonistic properties, can reduce impulsiveness and aggression in neuroleptic-resistant chronic schizophrenic patients, Fourteen neuroleptic-resistant chronic schizophrenic patients were treated with clozapine and prospectively evaluated for aggressiveness and impulsiveness for 18 weeks. Clozapine treatment induced a marked decrease in impulsiveness (32% on the impulsivity Scale; p <0.0001) and aggressiveness (98% on the Overt Aggression Scale; p <0.0001). We conclude that clozapine treatment may be effective in reducing psychotic symptoms as well as in controlling aggressive and impulsive behavior in neuroleptic-resistant chronic schizophrenic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:27:04