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Titolo:
PET-CHARACTERIZATION OF [CARBONYL-C-11]WAY-100635 BINDING TO 5-HT1A RECEPTORS IN THE PRIMATE BRAIN
Autore:
FARDE L; GINOVART N; ITO H; LUNDKVIST C; PIKE VW; MCCARRON JA; HALLDIN C;
Indirizzi:
KAROLINSKA INST,DEPT CLIN NEUROSCI,PSYCHIAT SECT S-17176 STOCKHOLM SWEDEN HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,CHEM & ENGN CYCLOTRON UNIT LONDON W12 0HS ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 133, anno: 1997,
pagine: 196 - 202
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; RAT-BRAIN; IN-VIVO; SEROTONIN RECEPTORS; H-3 WAY-100635; RADIOLIGAND; PINDOLOL; PHARMACOLOGY; DEPRESSION; ANTAGONIST;
Keywords:
5-HT1A-RECEPTORS; POSITRON EMISSION TOMOGRAPHY; MONKEY BRAIN; [CARBONYL-C-11]WAY-100635; 8-OH-DPAT; BUSPIRONE; PINDOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Farde et al., "PET-CHARACTERIZATION OF [CARBONYL-C-11]WAY-100635 BINDING TO 5-HT1A RECEPTORS IN THE PRIMATE BRAIN", Psychopharmacology, 133(2), 1997, pp. 196-202

Abstract

[carbonyl-C-11]WAY-100635 is a new radioligand which can be used withpositron emission tomography (PET) to provide high contrast delineation of human brain regions that are rich in 5-HT1A receptors. In the present PET study, the binding of [carbonyl-C-11]WAY-100635 was characterized in the cynomolgus monkey brain. Pretreatment with each of the two reference compounds, WAY-100635 and 8-OH-DPAT, as well as the drugs buspirone and pindolol, induced a marked inhibition of [carbonyl-C-11]WAY-100635 binding in the neocortex and the raphe nuclei, A preliminary Scatchard analysis yielded 5-HT1A receptor density values of the same order as those that have been reported in vitro. The study shows that [carbonyl-C-11]WAY-100635 binds specifically to 5-HT1A receptors in the primate brain and has potential for determination of 5-HT1A receptor occupancy and density in psychiatric patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 03:03:33