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Titolo:
CHARACTERIZATION OF THE ETHANOL-LIKE DISCRIMINATIVE STIMULUS EFFECTS OF 5-HT RECEPTOR AGONISTS AS A FUNCTION OF ETHANOL TRAINING DOSE
Autore:
GRANT KA; COLOMBO G; GATTO GJ;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PHYSIOL & PHARMACOL,300 S HAWTHORNE RD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT COMPARAT MED WINSTON SALEM NC 27157
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 133, anno: 1997,
pagine: 133 - 141
Fonte:
ISI
Lingua:
ENG
Soggetto:
M-CHLOROPHENYLPIPERAZINE; SEROTONIN RECEPTORS; DRINKING RATS; ALCOHOL; TFMPP; PREFERENCE; RITANSERIN; INVOLVEMENT; SUBTYPES; MIXTURE;
Keywords:
ETHANOL; 5-HT; RATS; DRUG DISCRIMINATION; ALCOHOL; TFMPP; MCPP; RU 24969; CGS 12066B; 8-OH DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Grant et al., "CHARACTERIZATION OF THE ETHANOL-LIKE DISCRIMINATIVE STIMULUS EFFECTS OF 5-HT RECEPTOR AGONISTS AS A FUNCTION OF ETHANOL TRAINING DOSE", Psychopharmacology, 133(2), 1997, pp. 133-141

Abstract

A drug discrimination procedure was used to characterize the ethanol-like effects of a variety of 5-HT1 agonists. Previous studies found that the degree of substitution of the 5-HT1B/2C agonist TFMPP (m-trifluoromethylphenylpiperazine) depended on the training dose of ethanol. The present studies extend this initial finding to four additional 5-HTagonists with different selectivity for 5-HT1A, 5-HT1B, or 5-HT2C receptors: CGS 12066B (4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline maleate), mCPP [1-(3-chlorophenyl)piperazine diHCl], RU 24969 ethoxy-3(1,2,3,4-tetrahydro-4-pyridinyl]-1H-indole succinate and 8-OH DPAT [(+/-)-8-hydroxy-2-(di-n-propylamino)tetralin HBr]. Separate groups of rats were trained to discriminate 1.0 g/kg (n=7), 1.5 g/kg (n=6) or 2.0 g/kg (n=8) ethanol from water. Following training, three to five dosesof each 5-HT agonist were tested twice in each rat. The most selective 5-HT1B agonist tested, CCS 12066B (3-17 mg/kg; IF), completely substituted for the 1.0 g/kg ethanol, but not for 1.5 or 2.0 g/kg ethanol. Likewise, the 5-HT1B/2C agonist mCPP (0.56-1.7 mg/kg; IF) completely substituted only in the 1.0 g/kg ethanol training group. The 5-HT1A/1B agonist RU 24969 (0.1-3.0 mg/kg; IF) substituted for all training doses of ethanol, although in a lower proportion of the rats tested in the2.0 g/kg ethanol training group. Finally, the 5-HT1A agonist 8-OH DPAT (0.1-1.0 mg/kg; IF) did not substitute completely for any ethanol training dose. The results consistently show that agonists with 5-HT1B activity produce discriminative stimulus effects similar to low and intermediate, but not high, ethanol training doses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:14:28