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Titolo:
A DESCRIPTIVE AND QUANTITATIVE LIGHT AND ELECTRON-MICROSCOPY STUDY OFTHE AORTIC DEPRESSOR NERVE IN NORMOTENSIVE RATS
Autore:
FAZAN VPS; SALGADO HC; BARREIRA AA;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT NEUROL,A BANDEIRANTES 3900BR-14049900 RIBEIRAO PRET SP BRAZIL SCH MED TRIANGULO MINEIRO,DEPT BIOL SCI UBERABA MINAS GERAIS BRAZIL UNIV SAO PAULO,SCH MED RIBEIRAO PRETO,DEPT PHYSIOL RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,SCH MED RIBEIRAO PRETO,DEPT NEUROL RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,SCH MED RIBEIRAO PRETO,UNIV HOSP RIBEIRAO PRET SP BRAZIL
Titolo Testata:
Hypertension
fascicolo: 3, volume: 30, anno: 1997,
parte:, 2 supplemento:, S
pagine: 693 - 698
SICI:
0194-911X(1997)30:3<693:ADAQLA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CAROTID-SINUS NERVE; BARORECEPTOR; MORPHOLOGY; FIBERS;
Keywords:
RAT PERIPHERAL NERVOUS SYSTEM; AORTIC DEPRESSOR NERVE; PERIPHERAL NERVES; NERVE MORPHOLOGY; NORMAL NERVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
V.P.S. Fazan et al., "A DESCRIPTIVE AND QUANTITATIVE LIGHT AND ELECTRON-MICROSCOPY STUDY OFTHE AORTIC DEPRESSOR NERVE IN NORMOTENSIVE RATS", Hypertension, 30(3), 1997, pp. 693-698

Abstract

There is no literature report of a detailed morphologic study of the aortic depressor nerve. The aim of this study was to describe the general morphological aspects and to obtain morphometric parameters for the aortic depressor nerve of normotensive Wistar rats (n=12). Before the morphologic studies, nerves were isolated and pressure-nerve activity curves were obtained. Basal mean arterial pressure was 117+/-5 mm Hg, the systolic pressure threshold was 100+/-7 mm Hg, and mean arterialpressure at 50% of maximal activity was 115+/-5 mm Hg and the baroreceptor gain 1.99+/-0.09%/mm Hg. Semithin and thin sections of proximal and distal nerve segments were then examined by light and electron microscopy, respectively. The main nerve components were (1) unmyelinatedand myelinated axons; (2) Schwann cells; (3) capillary wall endothelial cells and pericytes; (4) collagen fibers in the epineurium and endoneurium and between perineurial cell layers; and (5) fibroblasts and mast cells. The depressor nerves were found to contain 204-996 axons per nerve, 80% of which, on average, were unmyelinated, with a 4:1 unmyelinated/myelinated axon ratio. The unmyelinated axon histogram was unimodal, with a mean diameter of 0.5+/-0.02 mu m. Myelinated fibers had axons averaging 1.3+/-0.06 mu m in diameter and representing 53% of the total fiber diameter. The ratio between axonal and total fiber diameter of myelinated fiber ranged from 0.4 to 0.8 and tended to increase with axon size. Proximal and distal segments were morphologically similar. Ln conclusion, the morphologic description of the depressor nerveprovides important data for further investigations of the structural basis of altered baroreflex responses in conditions such as arterial hypertension, aging, atherosclerosis, and peripheral neuropathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:36:59