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Titolo:
APOE GENOTYPE AND ALZHEIMERS-DISEASE IN ADULTS WITH DOWN-SYNDROME - METAANALYSIS
Autore:
PRASHER VP; CHOWDHURY TA; ROWE BR; BAIN SC;
Indirizzi:
UNIV BIRMINGHAM,QUEEN ELIZABETH PSYCHIAT HOSP,DEPT PSYCHIAT,MINDELSOHN WAY BIRMINGHAM B15 2QZ W MIDLANDS ENGLAND UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP BIRMINGHAM B15 2QZ W MIDLANDS ENGLAND
Titolo Testata:
American journal of mental retardation
fascicolo: 2, volume: 102, anno: 1997,
pagine: 103 - 110
SICI:
0895-8017(1997)102:2<103:AGAAIA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E GENOTYPES; AMYLOID-FORMING DISEASES; E EPSILON-2 ALLELE; AGE-OF-ONSET; DEMENTIA; PATHOLOGY; DURATION; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
V.P. Prasher et al., "APOE GENOTYPE AND ALZHEIMERS-DISEASE IN ADULTS WITH DOWN-SYNDROME - METAANALYSIS", American journal of mental retardation, 102(2), 1997, pp. 103-110

Abstract

The apoE gene polymorphism was examined in 100 adults with Down syndrome (with and without dementia) compared to 346 control subjects without mental retardation. Meta-analysis of available data (480 subjects) revealed that apolipoprotein E genotype distribution for people with Down syndrome was similar to that of the nonretarded population. Although no significant association between possession of the apoE epsilon 4allele and onset of Alzheimer's disease was found, subjects with the allele had a tendency towards lower age of onset of dementia. Subjectswith apoE epsilon 2 allele may not develop dementia and may have increased longevity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:47:53