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Titolo:
THE GLUR2 (GLUR-B) HYPOTHESIS - CA2-PERMEABLE AMPA RECEPTORS IN NEUROLOGICAL DISORDERS()
Autore:
PELLEGRINIGIAMPIETRO DE; GORTER JA; BENNETT MVL; ZUKIN RS;
Indirizzi:
UNIV FLORENCE,DIPARTIMENTO FARMACOL PRECLIN,VIALE GB MORGAGNI 65 I-50134 FLORENCE ITALY UNIV FLORENCE,CLIN MARIO AIAZZI MANCINI I-50134 FLORENCE ITALY INST NEUROBIOL NL-1098 SM AMSTERDAM NETHERLANDS YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461
Titolo Testata:
Trends in neurosciences
fascicolo: 10, volume: 20, anno: 1997,
pagine: 464 - 470
SICI:
0166-2236(1997)20:10<464:TG(H-C>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT CEREBRAL-ISCHEMIA; GLUTAMATE-OPERATED CHANNELS; RAT HIPPOCAMPAL-FORMATION; EXCITATORY AMINO-ACIDS; DELAYED NEURONAL DEATH; CENTRAL-NERVOUS-SYSTEM; SUBUNIT MESSENGER-RNA; GENE-EXPRESSION; GERBIL HIPPOCAMPUS; CA2+ PERMEABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Pellegrinigiampietro et al., "THE GLUR2 (GLUR-B) HYPOTHESIS - CA2-PERMEABLE AMPA RECEPTORS IN NEUROLOGICAL DISORDERS()", Trends in neurosciences, 20(10), 1997, pp. 464-470

Abstract

The abnormal influx of Ca2+ through glutamate receptor channels is thought to contribute to the loss of neurons associated with a number ofbrain disorders. Until recently, the NMDA receptor was the only glutamate receptor known to be Ca2+-permeable. It is now well established that AM PA receptors exist not only in Ca2+-impermeable but also in Ca2-permeable forms. AMPA receptors are encoded by four genes designatedgluRI (gluR-A) through gluR4 (gluR-D). The presence of the gloR2 subunit renders heteromeric AMPA receptor assemblies Ca2+-impermeable, Recent studies involving animal models of transient forebrain ischemia and epilepsy show that gluR2 mRNA is downregulated in vulnerable neurons. These observations suggest that downregulation of gluR2 gene expression may serve as a 'molecular switch' leading to the formation of Ca2+-permeable AMPA receptors and enhanced toxicity of endogenous glutamate following a neurological insult.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:13:21