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Titolo:
SIGNALING EVENTS FOLLOWING THE INTERACTION OF THE NEURONAL ADHESION MOLECULE F3 WITH THE N-TERMINAL DOMAIN OF TENASCIN-R
Autore:
XIAO ZC; HILLENBRAND R; SCHACHNER M; THERMES S; ROUGON G; GOMEZ S;
Indirizzi:
FAC SCI LUMINY,LAB GENET & PHYSIOL DEV,CNRS 9943,CASE 907 F-13288 MARSEILLE 9 FRANCE FAC SCI LUMINY,LAB GENET & PHYSIOL DEV,CNRS 9943 F-13288 MARSEILLE 9 FRANCE SWISS FED INST TECHNOL,DEPT NEUROBIOL ZURICH SWITZERLAND UNIV HAMBURG,ZENTRUM MOL NEUROBIOL HAMBURG GERMANY
Titolo Testata:
Journal of neuroscience research
fascicolo: 6, volume: 49, anno: 1997,
pagine: 698 - 709
SICI:
0360-4012(1997)49:6<698:SEFTIO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX GLYCOPROTEIN; PROMOTES NEURITE OUTGROWTH; MAP-KINASE ERK-2; CELL-ADHESION; OKADAIC ACID; RESPIRATORY BURST; SOLUBLE FORM; IN-VITRO; PROTEIN; F11;
Keywords:
TENASCIN-R; EXTRACELLULAR MATRIX; CELL ADHESION; NEURITE OUTGROWTH; REPULSION; F3/F11; IMMUNOGLOBULIN SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Z.C. Xiao et al., "SIGNALING EVENTS FOLLOWING THE INTERACTION OF THE NEURONAL ADHESION MOLECULE F3 WITH THE N-TERMINAL DOMAIN OF TENASCIN-R", Journal of neuroscience research, 49(6), 1997, pp. 698-709

Abstract

Interaction between the extracellular matrix protein tenascin-R and the neuronal adhesion molecule F3 might be involved in the formation ofneuronal networks, In this study, the fragment of tenascin-R comprising epithelial growth factor (EGF)-like repeats and the cysteine-rich NH2 terminal stretch (EGF-L), known to be inhibitory for growing neurites and repellent for growth cones, was used to investigate the signaling events following the F3/EGF-L interaction, We addressed this question using an in vitro test with F3-transfected Chinese hamster ovary (CHO) cells that allowed us to measure the kinetics, magnitude and specificity of the repellent effect resulting from the specific F3/EGF-L interaction, We showed that the repellent effect was counteracted by addition of the serine/threonine kinase and -phosphatase modulators (staurosporine, okadaic acid and H7) but not by modulators of tyrosine kinase or -phosphatases, This result indicates that the intracellular signals activated bg the repellent effect involve a serine/threonine kinase pathway Furthermore, the repellent effect of the EGF-L fragment for growth cones of cultured cerebellar neurons was also abolished by the identical modulators of serine/threonine kinase and -phosphatases. Theinhibition of neurite outgrowth from hippocampal neurons by EGF-L wasabolished in the presence of the serine threonine-kinase inhibitor H7, These results strongly suggest that the F3/tenascin-R interaction through EGF-L involves an intracellular activation of serine/threonine kinase(s) in all F3-expressing cells tested, (C) 1997 Wiley-Liss, Inc.

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Documento generato il 27/11/20 alle ore 13:44:56