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Titolo:
DIFFERENTIAL EXPRESSION OF THE CCK-A AND CCK-B GASTRIN RECEPTOR GENESIN HUMAN CANCERS OF THE ESOPHAGUS, STOMACH AND COLON/
Autore:
CLERC P; DUFRESNE M; SAILLAN C; CHASTRE E; ANDRE T; ESCRIEUT C; KENNEDY K; VAYSSE N; GESPACH C; FOURMY D;
Indirizzi:
CHU RANGUEIL,INST FEDERAT RECH LOUIS BUGNARD,INSERM U151 F-31052 TOULOUSE FRANCE CHU RANGUEIL,INST FEDERAT RECH LOUIS BUGNARD,INSERM U151 F-31052 TOULOUSE FRANCE HOP ST ANTOINE,INSERM U55 F-75571 PARIS FRANCE
Titolo Testata:
International journal of cancer
fascicolo: 6, volume: 72, anno: 1997,
pagine: 931 - 936
SICI:
0020-7136(1997)72:6<931:DEOTCA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
B GASTRIN RECEPTOR; CHOLECYSTOKININ RECEPTORS; ACTIVATION; CARCINOMAS; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Clerc et al., "DIFFERENTIAL EXPRESSION OF THE CCK-A AND CCK-B GASTRIN RECEPTOR GENESIN HUMAN CANCERS OF THE ESOPHAGUS, STOMACH AND COLON/", International journal of cancer, 72(6), 1997, pp. 931-936

Abstract

The expression of cholecystokinin (CCK) and gastrin (G) receptors in human gastrointestinal cancers remains poorly documented and is still of a controversial nature. We have measured the levels of mRNA for CCK-A and CCK-B/gastrin receptors using quantitative reverse transcription-polymerase chain reaction (RT-PCR) in primary digestive cancers and hepatic metastases. CCK-A-receptor mRNA was detected in 5 out of 8 esophageal cancers (0.1-1 fg/mu g), in 5 out of 8 gastric cancers (0.05-4.2 fg/mu g) and in 5 out of 12 colon cancers (0.1-1 fg/mu g RNA). CCK-B/gastrin mRNA was not detected in esophageal cancers but was detectedin 7 out of 8 gastric cancers (0.05-5.2 fg/mu g), and in only 2 out of 12 colon adenocarcinomas (0.05-1 fg/mu g RNA). The expression of theCCK-A receptor in esophageal, gastric and colon cancers and of the CCK-B/gastrin receptor in the majority of gastric adenocarcinomas screened may be an important indicator of the influence of CCK and gastrin of local or systemic origin on the growth of these cancers. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:59:53