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Titolo:
PULMONARY ARTERIAL SMOOTH-MUSCLE CONTRACTILITY IN HYPOXIA-INDUCED PULMONARY-HYPERTENSION
Autore:
GRIFFITH SL; RHOADES RA; PACKER CS;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS,635 BARNHILL DR,MS 374 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS INDIANAPOLIS IN 46202
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 77, anno: 1994,
pagine: 406 - 414
SICI:
8750-7587(1994)77:1<406:PASCIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURAL-CHANGES; RAT; GROWTH; CIRCULATION; RESPONSES; DISEASE; MYOSIN; HEART; CELL; LUNG;
Keywords:
FORCE-VELOCITY RELATIONSHIP; VASCULAR MUSCLE; LENGTH-TENSION CURVES; SMOOTH MUSCLE MECHANICS; PULMONARY CIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Griffith et al., "PULMONARY ARTERIAL SMOOTH-MUSCLE CONTRACTILITY IN HYPOXIA-INDUCED PULMONARY-HYPERTENSION", Journal of applied physiology, 77(1), 1994, pp. 406-414

Abstract

The highly compliant low-resistance pulmonary vasculature is markedlyaltered with chronic hypoxia. Remodeling in response to hypoxia and/or hypertension involves hypertrophy and hyperplasia of smooth muscle and excessive deposition of connective tissue that likely contributes to the maintenance or exasperates the already elevated pulmonary arterial (PA) pressure. The purpose of this study was to investigate the effect of chronic hypoxia on the contractile properties of PA smooth muscle. Isometric and isotonic experiments were performed on excised PA rings from pulmonary hypertensive (induced by 14 days of hypoxia) Sprague-Dawley rats. A doubling of the vessel wall thickness occurred duringthe development of hypoxia-induced pulmonary hypertension. Functionally, there was a decrease in isometric stress (force to cross-sectionalarea ratio). No difference was detected in the velocity of shorteningor in total shortening ability. This study provides evidence that, inaddition to the morphological changes, changes in PA smooth muscle contractility also appear to play a role in the development and/or maintenance of hypoxia-induced pulmonary hypertension.

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Documento generato il 18/09/20 alle ore 17:18:17