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Titolo:
ATP-INDUCED KILLING OF MYCOBACTERIA BY HUMAN MACROPHAGES IS MEDIATED BY PURINERGIC P2Z(P2X(7)) RECEPTORS
Autore:
LAMMAS DA; STOBER C; HARVEY CJ; KENDRICK N; PANCHALINGAM S; KUMARARATNE DS;
Indirizzi:
UNIV BIRMINGHAM,SCH MED,DEPT IMMUNOL BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH MED,DEPT INFECT BIRMINGHAM B15 2TT W MIDLANDS ENGLAND CITY HOSP NHS TRUST,DEPT IMMUNOL BIRMINGHAM B18 7QH W MIDLANDS ENGLAND
Titolo Testata:
Immunity
fascicolo: 3, volume: 7, anno: 1997,
pagine: 433 - 444
SICI:
1074-7613(1997)7:3<433:AKOMBH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ATP; HUMAN-LYMPHOCYTES; CALMETTE-GUERIN; IFN-GAMMA; TUBERCULOSIS; INHIBITION; APOPTOSIS; LYSIS; CELLS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Lammas et al., "ATP-INDUCED KILLING OF MYCOBACTERIA BY HUMAN MACROPHAGES IS MEDIATED BY PURINERGIC P2Z(P2X(7)) RECEPTORS", Immunity, 7(3), 1997, pp. 433-444

Abstract

The death of BCG-infected human macrophages induced in vitro by ligation of surface CD95 (Fas), CD69, or complement-mediated lysis was shown not to result in the death of intracellular mycobacteria, whereas exposure to extracellular ATP initiated both macrophage death and killedthe intracellular bacteria. ATP acted via P2Z receptors because theseeffects were mimicked by benzoylbenzoic ATP (a known agonist of P2Z receptors) and blocked by oxidized ATP, DIDS, suramin, amiloride, and KN62 (known inhibitors of P2Z-mediated responses). ATP-mediated bacterial killing was independent of reactive nitrogen and oxygen intermediates and of actinomycin D or cycloheximide inhibition. ATP-induced macrophage cell death, BCG killing, and lucifer yellow dye incorporation were minimal in 2 out of 19 healthy donors. The results suggest possiblegenetic heterogeneity of this mechanism of mycobacterial killing associated with P2Z-mediated pore formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:16:53