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Titolo:
THE EFFECT OF PENTOXIFYLLINE ON CURRENT PERCEPTION THRESHOLDS IN PATIENTS WITH DIABETIC SENSORY NEUROPATHY
Autore:
LEE Y; ROBINSON M; WONG N; CHAN E; CHARLES MA;
Indirizzi:
UNIV CALIF IRVINE,DEPT MED,MED SCI ROOM C250 IRVINE CA 92717 UNIV CALIF IRVINE,DEPT MED IRVINE CA 92717
Titolo Testata:
Journal of diabetes and its complications
fascicolo: 5, volume: 11, anno: 1997,
pagine: 274 - 278
SICI:
1056-8727(1997)11:5<274:TEOPOC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Lee et al., "THE EFFECT OF PENTOXIFYLLINE ON CURRENT PERCEPTION THRESHOLDS IN PATIENTS WITH DIABETIC SENSORY NEUROPATHY", Journal of diabetes and its complications, 11(5), 1997, pp. 274-278

Abstract

Diabetic peripheral neuropathy is a common, painful, and disabling condition that is known to occur by two mechanisms: hyperglycemia and arterial blood flow occlusion. Pentoxifylline (Trental) functions by improving erythrocyte flexibility in blood vessels, which could increase the delivery of oxygen to occluded nerve vessels, This 1-year clinicaltrial was aimed at ascertaining the effects of pentoxifylline an diabetic sensory neuropathy. Fifty patients with type I or II diabetes were evaluated in a randomized, double-blind, parallel group and placebo-controlled study. Pentoxifylline effectiveness was evaluated by measuring glycated hemoglobin, blood pressure and current perception threshold (CPT), The CPT results showed no statistically significant effect of pentoxifylline on mean nerve sensory perception thresholds in ankle and toe at 5, 250 and 2000 Hz, There were no significant changes in glycated hemoglobin or in systolic and diastolic blood pressure during the trial, Thus, glycated hemoglobin and blood pressure did not explainthe lack of pentoxifylline effect an diabetic neuropathy. In conclusion, pentoxifylline appears not to add benefits to the clinical treatment of diabetic sensory neuropathy of the lower extremity. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:02:56