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Titolo:
PROGNOSTIC FACTORS OF HEMOPHAGOCYTIC SYNDROME IN ADULTS - ANALYSIS OF34 CASES
Autore:
KAITO K; KOBAYASHI M; KATAYAMA T; OTSUBO H; OGASAWARA Y; SEKITA T; SAEKI A; SAKAMOTO M; NISHIWAKI K; MASUOKA H; SHIMADA T; YOSHIDA M; HOSOYA T;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU,3-19-18 NISHI SHINBASHI TOKYO 105 JAPAN KASHIWA CITY HOSP,DEPT CENT LABS TOKYO JAPAN KASHIWA CITY HOSP,DEPT GEN INTERNAL MED TOKYO JAPAN
Titolo Testata:
European journal of haematology
fascicolo: 4, volume: 59, anno: 1997,
pagine: 247 - 253
SICI:
0902-4441(1997)59:4<247:PFOHSI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT HISTIOCYTOSIS; LYMPHOMA; PROLIFERATION;
Keywords:
HEMOPHAGOCYTIC SYNDROME; PROGNOSIS MALIGNANT HISTIOCYTOSIS; REACTIVE HEMOPHAGOCYTOSIS; OLDER AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Kaito et al., "PROGNOSTIC FACTORS OF HEMOPHAGOCYTIC SYNDROME IN ADULTS - ANALYSIS OF34 CASES", European journal of haematology, 59(4), 1997, pp. 247-253

Abstract

Hemophagocytic syndrome (HPS) presents with fever, pancytopenia, liver dysfunction and increase in hemophagocytic histiocytes in various organs. Although there are two major classifications of HPS in adults, malignant and reactive histiocytosis, it is often very difficult to distinguish between these disorders. We analyzed the laboratory data of patients with HPS to evaluate prognostic factors. Of 34 patients, 14 survived, and 20 died. The median age of survivors was 29.6+/-11.5 yr significantly younger than those who died (54.7+/-17.8 yr). Twenty patients had no obvious underlying disease, the other 13 had hematological malignancies or viral infections. Comparison of laboratory data revealed that nonsurvivors had significantly lower Hb and platelet values onadmission. During treatment, worsening of anemia and thrombocytopenia, increase of transaminase and biliary enzymes were similarly more prominent. Risk factors associated with death were: age over 30 yr, presence of disseminated intravascular coagulation, increased ferritin and beta(2)-microglobulin, anemia accompanied by thrombocytopenia and jaundice. Our data suggests that patients with HPS and any of these risk factors should be treated aggressively with sufficient chemotherapy andsupportive care.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:14:39