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Titolo:
DOPAMINE D-2 RECEPTOR IMAGING AND NEUROLEPTIC DRUG RESPONSE
Autore:
HEINZ A; KNABLE MB; WEINBERGER DR;
Indirizzi:
ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,CLIN BRAIN DISORDERS BRANCH,DIV INTRAMURAL RES PROGRAMS WASHINGTON DC 20032 ST ELIZABETH HOSP,NIMH,CTR NEUROSCI,CLIN BRAIN DISORDERS BRANCH,DIV INTRAMURAL RES PROGRAMS WASHINGTON DC 20032
Titolo Testata:
The Journal of clinical psychiatry
, volume: 57, anno: 1996, supplemento:, 11
pagine: 84 - 88
SICI:
0160-6689(1996)57:<84:DDRIAN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; ATYPICAL NEUROLEPTICS; CLINICAL-RESPONSE; BASAL GANGLIA; HUMAN BRAIN; OCCUPANCY; CLOZAPINE; BLOCKADE; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Heinz et al., "DOPAMINE D-2 RECEPTOR IMAGING AND NEUROLEPTIC DRUG RESPONSE", The Journal of clinical psychiatry, 57, 1996, pp. 84-88

Abstract

Studies with positron emission tomography and single photon emission computed tomography have yielded important findings concerning the relationship between dopamine D-2 receptor occupancy and neuroleptic dose, plasma neuroleptic levels. and clinical response. For ''typical'' neuroleptics, therapeutic response is associated with occupancy levels as lour as 60%-70%, which can be achieved at lower doses than are routinely used. For these drugs, extrapyramidal side effects increase, and therapeutic response remains unchanged with higher occupancy levels. Although the mechanisms responsible for the improved clinical efficacy and tolerability of atypical neuroleptics are still poorly understood,antipsychotic efficacy has been observed at lower D-2 receptor occupancy rates than with typical neuroleptics. It is unclear whether the lower incidence of extrapyramidal side effects observed with the atypical neuroleptic clozapine can be attributed to its lower D-2 occupancy, its relatively specific effects on the ventral striatum, or its nondopaminergic effects. There are a number of additional unresolved issues,including the high interindividual variation in scan outcome measurements, possible effects of concomitant medication, possible effects of endogenous dopamine, and assumptions in various strategies used to model receptor densities and occupancy rates.

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Documento generato il 17/01/20 alle ore 20:10:27