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Titolo:
INSERTION DELETION POLYMORPHISM OF THE ANGIOTENSIN-I-CONVERTING-ENZYME GENE IN PATIENTS WITH HYPERTENSION, NON-INSULIN-DEPENDENT DIABETES-MELLITUS, AND CORONARY HEART-DISEASE IN TAIWAN/
Autore:
CHUANG LM; CHIU KC; CHIANG FT; LEE KC; WU HP; LIN BJ; TAI TY;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 100 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,GRAD INST CLIN MED TAIPEI TAIWAN UNIV CALIF LOS ANGELES,SCH MED,DIV ENDOCRINOL & METAB LOS ANGELES CA 00000
Titolo Testata:
Metabolism, clinical and experimental
fascicolo: 10, volume: 46, anno: 1997,
pagine: 1211 - 1214
SICI:
0026-0495(1997)46:10<1211:IDPOTA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA ACE LEVELS; MYOCARDIAL-INFARCTION; DELETION POLYMORPHISM; I/D POLYMORPHISM; LINKAGE ANALYSIS; RETINOPATHY; NIDDM; RISK; SEGREGATION; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Chuang et al., "INSERTION DELETION POLYMORPHISM OF THE ANGIOTENSIN-I-CONVERTING-ENZYME GENE IN PATIENTS WITH HYPERTENSION, NON-INSULIN-DEPENDENT DIABETES-MELLITUS, AND CORONARY HEART-DISEASE IN TAIWAN/", Metabolism, clinical and experimental, 46(10), 1997, pp. 1211-1214

Abstract

An insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene has been identified that determines most of the plasma ACE activity genetically. Association of the D allele with insulin sensitivity and of the D/D genotype with coronary heart disease (CHD) has been reported in various ethnic populations. To study the roleof this genetic polymorphism in patients with hypertension, non-insulin-dependent diabetes mellitus (NIDDM), and NIDDM with CHD in a Taiwanese population, we used a polymerase chain reaction (PCR)-based genotyping technique with an insertion-specific primer for confirmation of the I allele. One hundred ninety-seven unrelated normal controls, 67 subjects with hypertension, 107 subjects with NIDDM, and 70 subjects with NIDDM and CHD were recruited for this study; all were Han Chinese. Subjects without a history of diabetes were studied by a standard 75-g oral glucose tolerance test. Hypertension was diagnosed according to the Fifth Joint National Committee criteria, and CHD was confirmed by ahistory of acute myocardial infarction and coronary angiographic intervention. The frequency of the I allele of the ACE gene in the normal population was 64.2%, which was higher than reported in white populations. The prevalence of the I allele of the ACE gene was not significantly increased in subjects with hypertension (73.1%), NIDDM (62.1%), and NIDDM with CHD (65%) compared with healthy controls. The I allele ofthe ACE gene did not correlate with demographic and metabolic variables. I/D polymorphism of the ACE gene is not a marker for hypertension,NIDDM, or CHD in this Taiwanese population. Copyright (C) 1997 by W.B. Saunders Company.

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Documento generato il 10/07/20 alle ore 02:07:42