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Titolo:
EFFECTS OF ACUTE METABOLIC STRESS ON PLASMA PROGESTERONE AND TESTOSTERONE IN MALE-SUBJECTS - RELATIONSHIP TO PITUITARY-ADRENOCORTICAL AXIS ACTIVATION
Autore:
ELMAN I; BREIER A;
Indirizzi:
NIMH,ETB,IRP,NIH,BLDG 10,ROOM 4N212,10 CTR DR BETHESDA MD 20892
Titolo Testata:
Life sciences
fascicolo: 17, volume: 61, anno: 1997,
pagine: 1705 - 1712
SICI:
0024-3205(1997)61:17<1705:EOAMSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; ADIPOSE-TISSUE INVIVO; MALE RHESUS MACAQUES; LUTEINIZING-HORMONE; INDUCED SUPPRESSION; MALE-RATS; SECRETION; CORTISOL; BINDING; MEN;
Keywords:
PROGESTERONE; TESTOSTERONE; 2-DEOXY-D-GLUCOSE; HPA AXIS; STRESS; GLUCOSE DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
I. Elman e A. Breier, "EFFECTS OF ACUTE METABOLIC STRESS ON PLASMA PROGESTERONE AND TESTOSTERONE IN MALE-SUBJECTS - RELATIONSHIP TO PITUITARY-ADRENOCORTICAL AXIS ACTIVATION", Life sciences, 61(17), 1997, pp. 1705-1712

Abstract

Stress effects on progesterone and testosterone as well as the relationship of these effects to the hypothalamic-pituitary-adrenal (HPA) axis activation have been extensively investigated in laboratory animals. There is less information about the impact of stress on sex steroidsin humans. The purpose of the present study was to examine the influence of acute metabolic stress on arterial levels of progesterone, testosterone, adrenocorticotropic hormone (ACTH), cortisol, gonadotropins and sex hormone binding globulin (SHBG) in healthy male subjects. The stressor used was glucoprivation induced by pharmacological doses of 2-deoxy-D-glucose (2DG) (40mg/kg). This stress resulted in increases inprogesterone, decreases in testosterone and no significant change in gonadotropins or SHBG. ACTH and cortisol were robustly elevated and these elevations related significantly to changes in progesterone but not testosterone. The implications of these data for the understanding of the role of sex steroids in the stress response is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:33:35