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Titolo:
NITRIC-OXIDE INHIBITS FAS-INDUCED APOPTOSIS
Autore:
MANNICK JB; MIAO XQ; STAMLER JS;
Indirizzi:
DANA FARBER CANC INST,DIV INFECT DIS,JFB 422,44 BINNEY ST BOSTON MA 02115 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DIV RESP DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DIV CARDIOVASC MED DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT CELL BIOL DURHAM NC 27710
Titolo Testata:
The Journal of biological chemistry
fascicolo: 39, volume: 272, anno: 1997,
pagine: 24125 - 24128
SICI:
0021-9258(1997)272:39<24125:NIFA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1-BETA CONVERTING ENZYME; MEDIATED APOPTOSIS; T-CELLS; LYMPHOPROLIFERATIVE SYNDROME; MONOCLONAL-ANTIBODY; SIGNALING COMPLEX; HIV-INFECTION; LPR/LPR MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Mannick et al., "NITRIC-OXIDE INHIBITS FAS-INDUCED APOPTOSIS", The Journal of biological chemistry, 272(39), 1997, pp. 24125-24128

Abstract

The Fas antigen (CD95, APO-1) is a transmembrane cell surface receptor that mediates apoptosis of many cell types when bound by Fas ligand or cross-linked by agonist antibody. The cellular factors regulating Fas-induced apoptosis have not been well defined. Here we show that basal nitric-oxide synthase (NOS) activity in human leukocytes inhibits Fas-induced apoptosis via a cGMP-independent mechanism. Further, NOS inhibits Fas-induced cleavage of poly(ADP-ribose) polymerase by members of the caspase family of cysteine proteases. These data suggest that Fas activity is under the control of the NO signaling pathway. NOS regulating the function of this member of the tumor necrosis factor receptor family suggests a new role for nitric oxide (or related molecules) in the human immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:53:00