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Titolo:
BIOLOGIC ALTERATIONS IN THE BRAIN-STEM OF SUICIDES
Autore:
ARANGO V; UNDERWOOD MD; MANN JJ;
Indirizzi:
NEW YORK STATE PSYCHIAT INST & HOSP,DEPT NEUROSCI,722 W 168TH ST,BOX 28 NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT ANAT & CELL BIOL NEW YORK NY10032 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT PSYCHIAT NEW YORK NY 10032 COLUMBIA UNIV,DEPT PSYCHIAT NEW YORK NY 00000
Titolo Testata:
The Psychiatric clinics of North America
fascicolo: 3, volume: 20, anno: 1997,
pagine: 581 -
SICI:
0193-953X(1997)20:3<581:BAITBO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID AMINE METABOLITES; DORSAL RAPHE NUCLEUS; EXHIBIT DIFFERENTIAL VULNERABILITY; TRITIATED IMIPRAMINE BINDING; ADRENERGIC-RECEPTOR BINDING; H-3 PAROXETINE BINDING; SEROTONIN UPTAKE SITES; 5-HT UPTAKE SITES; CEREBROSPINAL-FLUID; FRONTAL-CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
V. Arango et al., "BIOLOGIC ALTERATIONS IN THE BRAIN-STEM OF SUICIDES", The Psychiatric clinics of North America, 20(3), 1997, pp. 581

Abstract

This article reviews the data supporting the notion that there are alterations in serotonin and norepinephrine in the ventral prefrontal cortex and brainstem of suicide victims. Normal amounts of serotonin arefound in terminal fields such as the dorsolateral prefrontal cortex, but serotonin responses are defective at least in the hypothalamus. Suicide victims appear to have fewer noradrenergic LC neurons, containing more of the tyrosine hydroxylase enzyme needed for transmitter synthesis. A failure of behavior restraint mechanisms involving the prefrontal cortex as a consequence of alterations in brainstem monoaminergic nuclei may result in a predisposition to suicidal behavior.

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Documento generato il 22/01/20 alle ore 06:39:28